SOCS-3, Recombinant, Human (His) (CIS-3, Cytokine-inducible SH2-containing Protein-3, SSI-3, Suppressor of Cytokine Signaling-3, SOCS 3)[SOCS-3]

• Catalog number
  MBS637674
• Price
  Please ask
• Size
  NA

• Products_type
  Recombinant Protein
• Description
  Cytokines and Chemokines are chemotaxis related small proteins between 5 to 20 kDa. Cell nucleus signaling proteins and molecules are part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity as well as normal tissue homeostasis. Errors in cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated effectively and, theoretically, artificial tissues may be created. Kinase, breast cancer tumor, HRAS like - suppressor protein make genetic suppression restoring the phenotype seen prior to the original background in biological pathways.
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  SOCS-3   His   CIS-3   Cytokine   SH2   Protein-3   SSI-3   Suppressor   Cytokine   Signaling-3   SOCS   [SOCS-3]  
• Gene symbol
  SOCS3, CISH, SOCS1, MIR1302-3, MIR509-3, MIR7-3, PIRC13, PIRC11
• Short name
  SOCS-3, Recombinant, (His) (CIS-3, Cytokine- SH2- Protein-3, SSI-3, Suppressor of Cytokine Signaling-3, SOCS 3)[SOCS-3]
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. MyBioSource advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Host
  Human, E Coli
• Label
  His
• Species
  Human, Humans
• Alternative name
  SOCS-3, Rec., H. sapiens (histidine) (CIS-3, Cytokine-inducible SH2-containing Protein-3, SSI-3, Suppressor on Cytokine Signaling-3, SOCS 3)[SOCS-3]
• Alternative technique
  rec

Gene info

• Identity
  HGNC:19391
• Gene
  SOCS3
• Long gene name
  suppressor of cytokine signaling 3
• Synonyms
  • SSI-3
  • CIS3
  • SOCS-3
  • Cish3
• GenBank acession
  • AB004904
• Locus
  17q25.3
• Discovery year
  2002-11-13
• Entrez gene record
  9021
• Pubmed identfication
  • 9266833
  • 9344848
• Classification
  • Suppressors of cytokine signaling
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000177513
• Locus Specific Databases
  • LRG_619

Gene info

• Identity
  HGNC:1984
• Gene
  CISH
• Long gene name
  cytokine inducible SH2 containing protein
• Synonyms gene name
  • cytokine inducible SH2-containing protein
• Synonyms
  • CIS
  • G18
  • CIS-1
  • SOCS
• GenBank acession
  • Z77852
• Locus
  3p21.2
• Discovery year
  1996-09-23
• Entrez gene record
  1154
• Pubmed identfication
  • 9465889
  • 7796808
• RefSeq identity
  • NM_145071
• Classification
  • Suppressors of cytokine signaling
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000156853

Gene info

• Identity
  HGNC:19383
• Gene
  SOCS1
• Long gene name
  suppressor of cytokine signaling 1
• Synonyms
  • SOCS-1
  • SSI-1
  • JAB
  • TIP3
  • Cish1
• GenBank acession
  • U88326
• Locus
  16p13.13
• Discovery year
  2002-11-13
• Pubmed identfication
  • 7796808
  • 9266833
• Classification
  • Suppressors of cytokine signaling
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000129792

Gene info

• Identity
  HGNC:35295
• Gene
  MIR1302-3
• Long gene name
  microRNA 1302-3
• Synonyms gene
  • MIRN1302-3
• Synonyms
  • hsa-mir-1302-3
• Locus
  2q14.1
• Discovery year
  2008-11-03
• Entrez gene record
  100302128
• RefSeq identity
  • NR_031632
• Classification
  • MicroRNA MIR1302 family

Gene info

• Identity
  HGNC:33675
• Gene
  MIR509-3
• Long gene name
  microRNA 509-3
• Synonyms gene
  • MIRN509-3
• Synonyms
  • hsa-mir-509-3
• Locus
  Xq27.3
• Discovery year
  2007-10-24
• Entrez gene record
  100126337
• RefSeq identity
  • NR_030629
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:31640
• Gene
  MIR7-3
• Long gene name
  microRNA 7-3
• Synonyms gene
  • MIRN7-3
• Synonyms
  • hsa-mir-7-3
• Locus
  19p13.3
• Discovery year
  2004-04-23
• Entrez gene record
  407045
• RefSeq identity
  • NR_029607
• Classification
  • MicroRNA MIR7 family

Gene info

• Identity
  HGNC:37517
• Gene
  PIRC13
• Long gene name
  piwi-interacting RNA cluster 13
• Locus
  3
• Discovery year
  2009-11-05
• Entrez gene record
  100313925
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37515
• Gene
  PIRC11
• Long gene name
  piwi-interacting RNA cluster 11
• Locus
  3
• Discovery year
  2009-11-05
• Entrez gene record
  100313897
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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