Sheep Polyclonal (IgG) to Human EGFR

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Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
About

Immunoglobulin gamma, IgG, mouse monoclonal H&L chain clones or rabbit, goat polyclonal antibodies have 4 parts. There are 2 heavy chains, 2 light chains. The IgG antibody has 2 antigen binding sites. They represent 70% or more of serum antibodies. This antibody can be antigen purified or protein A or G purified. For storage sodium azide is added or you can call us to request azide free antibody preparations. These will need colder storage temperatures. Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
Group

Polyclonals and antibodies

Gene target

EGFR
Gene symbol

EGFR-AS1, EGILA, EGFR, RHBDF1
Short name

Polyclonal (IgG) EGFR
Technique

Polyclonal, IgG, IgGs, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
Host

Sheep
Isotype

IgG, IgG
Species

Human, Humans, The sheep (Ovis aries) ELISAs are detecting sheep proteins and antigens. Some epitopes will also recognize goat proteins. Sheep and goats are also used to produce polyclonals. An adult female sheep is referred to as a ewe a male as a ram, a castrated male as a wether, and a younger sheep as a lamb. Sheeps
Alternative name

ovine polyclonal (Immunoglobulin G) to H. sapiens epidermal growth factor receptor
Alternative technique

polyclonals, immunoglobulins
Alternative to gene target

epidermal growth factor receptor, ERBB and ERBB1 and HER1 and mENA and PIG61, EGFR and IDBG-16933 and ENSG00000146648 and 1956, transferase activity, nuclei, Egfr and IDBG-151194 and ENSMUSG00000020122 and 13649, EGFR and IDBG-644035 and ENSBTAG00000011628 and 407217

Identity

HGNC:3236
Gene

EGFR
Long gene name

epidermal growth factor receptor
Synonyms gene
- ERBB
Synonyms gene name
- epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)
Synonyms
- ERBB1
- ERRP
Synonyms name
- erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian)
- erb-b2 receptor tyrosine kinase 1
Locus

7p11.2
Discovery year

1986-01-01
Entrez gene record

1956
Pubmed identfication
- 1505215
RefSeq identity
- NM_005228
Classification
- Erb-b2 receptor tyrosine kinases
VEGA ID

OTTHUMG00000023661
Locus Specific Databases
- LRG_304

Identity

HGNC:20561
Gene

RHBDF1
Long gene name

rhomboid 5 homolog 1
Synonyms gene
- C16orf8
Synonyms gene name
- chromosome 16 open reading frame 8
- rhomboid family 1 (Drosophila)
- rhomboid 5 homolog 1 (Drosophila)
Synonyms
- EGFR-RS
- FLJ2235
- Dist1
- iRhom1
GenBank acession
- BC014425
Locus

16p13.3
Discovery year

2003-04-07
Entrez gene record

64285
Pubmed identfication
- 8318735
- 15965977
RefSeq identity
- NM_022450
Classification
- Rhomboid family
VEGA ID

OTTHUMG00000060719