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Products_type
Antibody
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Products_short_name
[Ryanodine Receptor 1,2]
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Products_name_syn
[Anti -Ryanodine Receptor 1,2 (RyR)]
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Other_names
[ryanodine receptor 1; Type 1-like ryanodine receptor; ryanodine receptor 1; ryanodine receptor type1; central core disease of muscle; type 1-like ryanodine receptor; skeletal muscle ryanodine receptor; skeletal muscle calcium release channel; sarcoplasmic reticulum calcium release channel; ryanodine receptor 1 (skeletal)]
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Other_gene_names
[RYR1; CCO; MHS; RYR; MHS1; RYDR; SKRR; RYR-1]
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Clonality
Monoclonal
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Clone
[8.BI.500]
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Reactivity
Bovine, Canine, Chicken, Frog, Human, Mouse, Rat, Sheep
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Specificity
Recognizes 565kD RyR-1 and RyR-2 in bovine, canine, human, mouse, rat and sheep. Crossreacts with chicken RyRa, RyRb and cardiac isoforms and frog RyRa and RyRb isoforms.
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Purity
Ascites Neat ascites
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Form
Supplied as a liquid with 0.05% sodium azide.
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Storage_stability
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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Tested_application
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF)
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Description
The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
