Recombinant Rat Interleukin-1 Receptor Antagonist

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Description

The antagonist receptor ligand binding will be in contrast with agonist activity. MyBioSource produces more antagonist and receptor related products as 1. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
About

Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
Latin name

Rattus norvegicus
Source

Recombinants or rec. proteins
Group

recombinants

Gene target

Interleukin-1 Receptor Antagonist
Gene symbol

IL1RN, IL36RN, IL1F10
Short name

Recombinant Interleukin-1 Receptor Antagonist
Technique

Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. MyBioSource advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
Host

Rat
Species

Rat, Rats
Alternative name

Rec. Rat Interleukin-1 Receptor Antagonist
Alternative technique

rec

Identity

HGNC:6000
Gene

IL1RN
Long gene name

interleukin 1 receptor antagonist
Synonyms
- IL1RA
- ICIL-1RA
- IL1F3
- IRAP
- IL-1RN
- MGC10430
Synonyms name
- interleukin-1 receptor antagonist protein
- intracellular interleukin-1 receptor antagonist
GenBank acession
- M55646
Locus

2q14.1
Discovery year

1990-11-20
Entrez gene record

3557
Pubmed identfication
- 1386337
- 8432529
RefSeq identity
- NM_173841
Classification
- Interleukins
- Interleukin receptors
VEGA ID

OTTHUMG00000131341
Locus Specific Databases
- LRG_188

Name

Primary Cell Culture
Concept

Scope note: The initial culturing of cells derived directly from fresh TISSUES.
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
Qualifiers

ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data