Recombinant Human DNA mismatch repair protein Mlh1 (MLH1), partial

Products_type

Recombinant Protein
Products_short_name

[DNA mismatch repair protein Mlh1 (MLH1)]
Products_name_syn

[Recombinant Human DNA mismatch repair protein Mlh1 (MLH1) (His tagged); DNA mismatch repair protein Mlh1; MutL protein homolog 1]
Other_names

[DNA mismatch repair protein Mlh1 isoform 1; DNA mismatch repair protein Mlh1; DNA mismatch repair protein Mlh1; mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); MutL protein homolog 1]
Products_gene_name

[MLH1]
Products_gene_name_syn

[COCA2]
Other_gene_names

[MLH1; MLH1; FCC2; COCA2; HNPCC; hMLH1; HNPCC2; COCA2]
Purity

>85% (SDS-PAGE)
Form

Lyophilized or liquid (Format to be determined during the manufacturing process)
Storage_stability

Store at -20 degree C. For extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Source

Recombinants or rec. proteins
Group

recombinants

Gene target

DNA mismatch repair protein Mlh1 MLH1 partial
Gene symbol

MLH1, PRKDC, HLA-DOA
Short name

Recombinant DNA mismatch repair protein Mlh1 (MLH1), partial
Technique

Recombinant, dna, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. MyBioSource advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
Host

E Coli or Yeast or Baculovirus or Mammalian Cell
Species

Human, Humans
Alternative name

Rec. H. sapiens Desoxyribonucleic acid mismatch repair protein mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)), partial
Alternative technique

rec
Alternative to gene target

mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli), COCA2 and FCC2 and hMLH1 and HNPCC and HNPCC2, MLH1 and IDBG-24600 and ENSG00000076242 and 4292, structure-specific DNA binding, nuclei, Mlh1 and IDBG-202755 and ENSMUSG00000032498 and 17350, MLH1 and IDBG-644253 and ENSBTAG00000016758 and 533652

Identity

HGNC:7127
Gene

MLH1
Long gene name

mutL homolog 1
Synonyms gene
- COCA2
Synonyms gene name
- mutL (E. coli) homolog 1 (colon cancer, nonpolyposis type 2)
- mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
Synonyms
- HNPCC
- FCC2
- HNPCC2
GenBank acession
- U07418
Locus

3p22.2
Discovery year

1993-11-24
Entrez gene record

4292
Pubmed identfication
- 7903889
RefSeq identity
- NM_000249
Classification
- MutL homologs
VEGA ID

OTTHUMG00000130797
Locus Specific Databases

Name

Targeted Gene Repair
Concept

Scope note: A technique which uses synthetic oligonucleotides to direct the cell's inherent DNA repair system to correct a mutation at a specific site in an episome or chromosome.
Tree numbers
- E02.095.301.500
- E05.393.420.301.500
- E05.393.420.601.575.500
Qualifiers

legislation & jurisprudence, ethics, mortality, psychology, trends, veterinary, history, classification, economics, instrumentation, methods, nursing, standards, adverse effects, statistics & numerical data