Rabbit Polyclonal (IgG) to Human CASP2 / Caspase 2

• Catalog number
  MBS244695
• Price
  Please ask
• Size
  0.05 mL

• Products_type
  Antibody
• Products_short_name
  [CASP2 / Caspase 2]
• Products_name_syn
  [Anti-CASP2 / Caspase 2 Antibody (aa123-172) IHC-plus; CASP2; CASP-2; Caspase-2; PPP1R57; Protease ICH-1; NEDD-2; Caspase 2; ICH1; NEDD2; Human CASP2; Caspase 2]
• Other_names
  [caspase-2 isoform 1 preproprotein; Caspase-2; caspase-2; protease ICH-1; protein phosphatase 1, regulatory subunit 57; neural precursor cell expressed developmentally down-regulated protein 2; caspase 2, apoptosis-related cysteine peptidase; Neural precursor cell expressed developmentally down-regulated protein 2; NEDD-2; Protease ICH-1Cleaved into the following 3 chains:Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
• Products_gene_name
  [CASP2]
• Other_gene_names
  [CASP2; CASP2; ICH1; NEDD2; CASP-2; NEDD-2; PPP1R57; ICH1; NEDD2; CASP-2; NEDD-2]
• Clonality
  Polyclonal
• Reactivity
  Human
• Specificity
  Caspase 2 Antibody detects endogenous levels of total Caspase 2 protein.
• Purity
  Immunoaffinity Purified
• Form
  PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
• Concentration
  1 mg/ml
• Storage_stability
  Long term: -20 degree C; Short term: +4 degree C; Avoid freeze-thaw cycles.
• Tested_application
  Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Description
  Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• About
  Immunoglobulin gamma, IgG, mouse monoclonal H&L chain clones or rabbit, goat polyclonal antibodies have 4 parts. There are 2 heavy chains, 2 light chains. The IgG antibody has 2 antigen binding sites. They represent 70% or more of serum antibodies. This antibody can be antigen purified or protein A or G purified. For storage sodium azide is added or you can call us to request azide free antibody preparations. These will need colder storage temperatures. Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera. Rabbits are used for polyclonal antibody production by MyBioSource. Rabbit antibodies are very stable and can be stored for several days at room temperature. MyBioSource adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Group
  Polyclonals and antibodies
• Latin name
  Oryctolagus cuniculus

• Gene target
  CASP2   Caspase  
• Gene symbol
  CASP2
• Short name
  Rabbit Polyclonal (IgG) CASP2 / Caspase 2
• Technique
  Polyclonal, Rabbit, IgG, IgGs, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Host
  Rabbit, Rabbits
• Isotype
  IgG, IgG
• Species
  Human, Humans
• Alternative name
  production species: rabbit polyclonal (Immunoglobulin G) to H. sapiens caspase 2, apoptosis-related cysteine peptidase / caspase 2
• Alternative technique
  polyclonals, rabbit-anti, immunoglobulins
• Alternative to gene target
  caspase 2, apoptosis-related cysteine peptidase, CASP-2 and ICH1 and NEDD-2 and NEDD2 and PPP1R57, CASP2 and IDBG-45836 and ENSG00000106144 and 835, cysteine-type endopeptidase activity involved in apoptotic process, nuclei, Casp2 and IDBG-141522 and ENSMUSG00000029863 and 12366, BT.103474 and IDBG-636898 and ENSBTAG00000018159 and 531419

Gene info

• Identity
  HGNC:1503
• Gene
  CASP2
• Long gene name
  caspase 2
• Synonyms gene
  • NEDD2
• Synonyms gene name
  • neural precursor cell expressed, developmentally down-regulated 2
  • caspase 2, apoptosis-related cysteine peptidase
• Synonyms
  • ICH1
  • PPP1R57
  • MGC2181
• Synonyms name
  • protein phosphatase 1, regulatory subunit 57
• GenBank acession
  • AK096245
  • BC002427
  • BM998653
  • BX537669
  • CB988674
  • U13021
• Locus
  7q34
• Discovery year
  1994-01-21
• Entrez gene record
  835
• Pubmed identfication
  • 7789948
  • 8780721
  • 19075813
• RefSeq identity
  • NM_032982
• Classification
  • Caspases
  • Caspase recruitment domain containing
  • Protein phosphatase 1 regulatory subunits
• VEGA ID
  OTTHUMG00000023641

MeSH Data

• Name
  Models, Chemical
• Concept
  Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
• Tree numbers
  • E05.599.495

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