RABBIT ANTI CDKN2A

• Catalog number
  MBS222939
• Price
  Please ask
• Size
  5x0.1 mg

• Products_type
  Antibody
• Products_short_name
  [CDKN2A]
• Other_names
  [cyclin-dependent kinase inhibitor 2A isoform p16INK4a; Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3; cyclin-dependent kinase inhibitor 2A; CDK4 inhibitor p16-INK4; CDKN2A; cell cycle negative regulator beta; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); multiple tumor suppressor 1; cyclin-dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A; CDK4I; Multiple tumor suppressor 1; MTS-1; p16-INK4a; p16-INK4; p16INK4A]
• Products_gene_name
  [CDKN2A]
• Other_gene_names
  [CDKN2A; CDKN2A; ARF; MLM; P14; P16; P19; CMM2; INK4; MTS1; TP16; CDK4I; CDKN2; INK4A; MTS-1; P14ARF; P19ARF; P16INK4; P16INK4A; P16-INK4A; CDKN2; MTS1; CDK4I; MTS-1; p16-INK4; p16INK4A]
• Clonality
  Polyclonal
• Reactivity
  Mouse, Rat
• Specificity
  This item recognises human cyclin-dependent kinase inhibitor 2A (CDKN2A), a 16kDa protein belonging to the CDKN2 cyclin dependent kinase inhibitor family. CDKN2A acts as a negative regulator of cell proliferation by interacting strongly with CDK4 and CDK6, thus inhibiting their ability to interact with cyclin D and to phosphorylate the retinoblastoma protein. CDKN2A is an important tumour suppressor and defects in its production results in tumour formation in a wide range of tissues, including cutaneous malignant melanoma and Li-Fraumeni syndrome.
• Form
  Purified Purified IgG - liquid
• Storage_stability
  Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
• Tested_application
  Immunohistology Paraffin*, Western Blot (WB)
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• About
  Rabbits are used for polyclonal antibody production by MyBioSource. Rabbit antibodies are very stable and can be stored for several days at room temperature. MyBioSource adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Latin name
  Oryctolagus cuniculus

• Gene target
  CDKN2A  
• Gene symbol
  CDKN2A-DT, CDKN2A
• Short name
  RABBIT ANTI CDKN2A
• Technique
  Rabbit, anti, antibody to
• Host
  Rabbit, Rabbits
• Isotype
  IgG
• Alternative name
  production species: rabbit antibody to cyclin-dependent phosphorylation catalyst inhibitor 2A
• Alternative technique
  rabbit-anti, antibodies
• Alternative to gene target
  cyclin-dependent kinase inhibitor 2A, ARF and CDK4I and CDKN2 and CMM2 and INK4 and INK4A and MLM and MTS-1 and MTS1 and P14 and P14ARF and P16 and P16-INK4A and P16INK4 and P16INK4A and P19 and P19ARF and TP16, CDKN2A and IDBG-54547 and ENSG00000147889 and 1029, MDM2/MDM4 family protein binding, nuclei, CDKN2A and IDBG-630043 and ENSBTAG00000034220 and 616369

Gene info

• Identity
  HGNC:23831
• Gene
  CDKN2A-DT
• Long gene name
  CDKN2A divergent transcript
• Synonyms gene
  • C9orf53
  • CDKN2A-AS1
• Synonyms gene name
  • chromosome 9 open reading frame 53
  • CDKN2A antisense RNA 1 (head to head)
• Synonyms
  • bA149I2.3
• GenBank acession
  • AF211119
• Locus
  9p21.3
• Discovery year
  2004-07-23
• Entrez gene record
  51198
• RefSeq identity
  • NR_024274
• Classification
  • Divergent transcripts
• VEGA ID
  OTTHUMG00000019687

Gene info

• Identity
  HGNC:1787
• Gene
  CDKN2A
• Long gene name
  cyclin dependent kinase inhibitor 2A
• Synonyms gene
  • CDKN2
  • MLM
• Synonyms gene name
  • cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
• Synonyms
  • CDK4I
  • p16
  • INK4a
  • MTS1
  • CMM2
  • ARF
  • p19
  • p14
  • INK4
  • p16INK4a
  • p19Arf
  • p14ARF
• GenBank acession
  • L27211
• Locus
  9p21.3
• Discovery year
  1994-05-19
• Entrez gene record
  1029
• Pubmed identfication
  • 8152487
  • 7606716
• RefSeq identity
  • NM_000077
• VEGA ID
  OTTHUMG00000019686
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_11

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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