Plasminogen Activator Inhibitor Type 1, Inhibitory (PAI-1)

• Catalog number
  MBS632488
• Price
  Please ask
• Size
  5x1 mg

• Products_type
  Antibody
• Products_short_name
  [Plasminogen Activator Inhibitor Type 1, Inhibitory]
• Products_name_syn
  [Anti -Plasminogen Activator Inhibitor Type 1, Inhibitory (PAI-1)]
• Other_names
  [plasminogen activator inhibitor type 1]
• Clonality
  Monoclonal
• Clone
  [9L781]
• Reactivity
  Human, Mouse
• Specificity
  Recognizes human PAI-1. Specific for plasminogen activator inhibitor-1 and exhibits inhibitory characteristics. The antibody binds to the F-Helix of PAI-1. This PAI-1/MoAB complex acts as a substrate for its target proteinases tPA and uPA. Species Crossreactivity: mouse.
• Purity
  Affinity Purified Purified by Protein A affinity chromatography.
• Form
  Supplied as a liquid in 0.05M sodium phosphate, 0.1M sodium chloride, pH 7.4.
• Storage_stability
  May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
• Tested_application
  ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
• Gene
  Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor or serpin E1 is a protein that in humans is encoded by the SERPINE1 gene. Elevated PAI-1 is a risk factor for thrombosis and atherosclerosis

• Gene target
  Plasminogen   Activator   Inhibitor   Inhibitory   PAI-1  
• Gene symbol
  SERPINE1, SERPINB2, SERBP1, IGHVII-1-1, MIR1-1, TRUND-NNN8-1, TRUND-NNN7-1, IGKV1OR2-1, MIR101-1, MIR1289-1
• Short name
  Plasminogen Activator Inhibitor 1, Inhibitory (PAI-1)
• Host
  Mouse
• Isotype
  IgG1
• Alternative name
  Plasminogen Activator suppressor classification 1, Inhibitory (PAI-1)

Gene info

• Identity
  HGNC:8583
• Gene
  SERPINE1
• Long gene name
  serpin family E member 1
• Synonyms gene
  • PLANH1
  • PAI1
• Synonyms gene name
  • serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
• Synonyms
  • PAI
• Synonyms name
  • plasminogen activator inhibitor, type I
• GenBank acession
  • M16006
• Locus
  7q22.1
• Discovery year
  1986-01-01
• Entrez gene record
  5054
• Pubmed identfication
  • 3097076
  • 2891140
  • 24172014
• RefSeq identity
  • NM_000602
• Classification
  • Serpin peptidase inhibitors
• VEGA ID
  OTTHUMG00000157107
• Locus Specific Databases
  • LRG_597

Gene info

• Identity
  HGNC:8584
• Gene
  SERPINB2
• Long gene name
  serpin family B member 2
• Synonyms gene
  • PLANH2
  • PAI2
• Synonyms gene name
  • serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2
  • serpin peptidase inhibitor, clade B (ovalbumin), member 2
• Synonyms
  • HsT1201
  • PAI-2
• Synonyms name
  • plasminogen-activator inhibitor
• GenBank acession
  • Y00630
• Locus
  18q21.33-q22.1
• Discovery year
  1989-02-07
• Entrez gene record
  5055
• Pubmed identfication
  • 24172014
• RefSeq identity
  • NM_002575
• Classification
  • Serpin peptidase inhibitors
• VEGA ID
  OTTHUMG00000060592

Gene info

• Identity
  HGNC:17860
• Gene
  SERBP1
• Long gene name
  SERPINE1 mRNA binding protein 1
• Synonyms
  • PAI-RBP1
  • DKFZP564M2423
  • CGI-55
  • HABP4L
  • PAIRBP1
  • CHD3IP
• GenBank acession
  • AF151813
• Locus
  1p31.3
• Discovery year
  2005-09-15
• Entrez gene record
  26135
• Pubmed identfication
  • 11001948
  • 10810093
  • 18440126
  • 17698176
• RefSeq identity
  • NM_001018067
• VEGA ID
  OTTHUMG00000009372

Gene info

• Identity
  HGNC:5670
• Gene
  IGHVII-1-1
• Long gene name
  immunoglobulin heavy variable (II)-1-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable (II)-1-1
  • immunoglobulin heavy variable (II)-1-1 pseudogene
• Synonyms
  • IGHV(II)-1-1
• GenBank acession
  • AB019441
• Locus
  14q32.33
• Discovery year
  2000-04-17
• Entrez gene record
  28377
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152325

Gene info

• Identity
  HGNC:31499
• Gene
  MIR1-1
• Long gene name
  microRNA 1-1
• Synonyms gene
  • MIRN1-1
• Synonyms
  • hsa-mir-1-1
• Locus
  20q13.33
• Discovery year
  2004-04-23
• Entrez gene record
  406904
• RefSeq identity
  • NR_029780
• Classification
  • MicroRNA MIR1/206 family

Gene info

• Identity
  HGNC:50820
• Gene
  TRUND-NNN8-1
• Long gene name
  tRNA-undetermined (NNN) 8-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 8-1
• GenBank acession
  • HG984097
• Locus
  1
• Discovery year
  2014-06-20
• Entrez gene record
  103482528
• Pubmed identfication
  • 18984615

Gene info

• Identity
  HGNC:50819
• Gene
  TRUND-NNN7-1
• Long gene name
  tRNA-undetermined (NNN) 7-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 7-1
• GenBank acession
  • HG984096
• Locus
  1
• Discovery year
  2014-06-20
• Entrez gene record
  103482531
• Pubmed identfication
  • 18984615

Gene info

• Identity
  HGNC:5760
• Gene
  IGKV1OR2-1
• Long gene name
  immunoglobulin kappa variable 1/OR2-1 (pseudogene)
• Synonyms gene
  • IGKVPZ1
  • IGKV1OR-1
• Synonyms gene name
  • immunoglobulin kappa variable 1/OR-1
  • immunoglobulin kappa variable 1/OR-1 pseudogene
  • immunoglobulin kappa variable 1/OR-1 (pseudogene)
• Synonyms
  • IGKV1/OR-1
  • IGKV1/OR2-1
• GenBank acession
  • Z12367
• Locus
  2p11.1
• Discovery year
  2000-04-18
• Entrez gene record
  3531
• Pubmed identfication
  • 2853098
• Classification
  • Immunoglobulin kappa (IGK) orphons
• VEGA ID
  OTTHUMG00000155081

Gene info

• Identity
  HGNC:31488
• Gene
  MIR101-1
• Long gene name
  microRNA 101-1
• Synonyms gene
  • MIRN101-1
• Synonyms
  • hsa-mir-101-1
• Locus
  1p31.3
• Discovery year
  2004-04-23
• Entrez gene record
  406893
• RefSeq identity
  • NR_029516
• Classification
  • MicroRNA MIR101 family

Gene info

• Identity
  HGNC:35281
• Gene
  MIR1289-1
• Long gene name
  microRNA 1289-1
• Synonyms gene
  • MIRN1289-1
• Synonyms
  • hsa-mir-1289-1
• Locus
  20q11.22
• Discovery year
  2008-11-03
• Entrez gene record
  100302125
• RefSeq identity
  • NR_031620
• Classification
  • MicroRNA MIR1289 family

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