PD-325901, Free Base (PD 0325901, MEK1/2 Inhibitor III)

Other size

please contact us to order other different size
Description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Gene target

PD-325901 Free Base 0325901 MEK1/2 Inhibitor III
Gene symbol

MAP2K1, CPLX3, ENPP2, MGAT3, MGST3, PDCD1, P4HA3, CASP5, ENPP3, THAP4
Short name

PD-325901, Free Base (PD 0325901, MEK1/2 Inhibitor III)
Alternative name

PD-325901, Free Base (PD 0325901, MEK1/2 suppressor III)

Identity

HGNC:7046
Gene

MGAT3
Long gene name

beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Synonyms gene name
- mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
Synonyms
- GNT-III
GenBank acession
- D13789
Locus

22q13.1
Discovery year

1993-08-27
Entrez gene record

4248
Pubmed identfication
- 8370666
RefSeq identity
- NM_002409
Classification
- Mannosyl-glycoprotein N-acetylglucosaminyltransferases
VEGA ID

OTTHUMG00000030185

Identity

HGNC:30135
Gene

P4HA3
Long gene name

prolyl 4-hydroxylase subunit alpha 3
Synonyms gene name
- procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III
- prolyl 4-hydroxylase, alpha polypeptide III
Synonyms
- C-P4Halpha(III)
Synonyms name
- collagen prolyl 4-hydroxylase alpha(III)
GenBank acession
- AY327887
Locus

11q13.4
Discovery year

2004-05-12
Entrez gene record

283208
Pubmed identfication
- 14500733
RefSeq identity
- NM_182904
VEGA ID

OTTHUMG00000165254

Identity

HGNC:1506
Gene

CASP5
Long gene name

caspase 5
Synonyms gene name
- caspase 5, apoptosis-related cysteine protease
- caspase 5, apoptosis-related cysteine peptidase
Synonyms
- ICE(rel)III
Locus

11q22.3
Discovery year

1996-09-13
Entrez gene record

838
Pubmed identfication
- 7797592
- 9250871
RefSeq identity
- NM_004347
Classification
- Caspases
- Caspase recruitment domain containing
VEGA ID

OTTHUMG00000048073

Identity

HGNC:3358
Gene

ENPP3
Long gene name

ectonucleotide pyrophosphatase/phosphodiesterase 3
Synonyms gene
- PDNP3
Synonyms
- PD-IBETA
- gp130RB13-6
- B10
- CD203c
GenBank acession
- AF005632
Locus

6q23.2
Discovery year

1995-08-10
Entrez gene record

5169
Pubmed identfication
- 9344668
Classification
- Ectonucleotide pyrophosphatase/phosphodiesterase family
- CD molecules
VEGA ID

OTTHUMG00000016292