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Products_type
Antibody
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Products_short_name
[Nicotinic Receptor, alpha 4]
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Products_name_syn
[Anti -Nicotinic Receptor, alpha 4]
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Other_names
[neuronal acetylcholine receptor subunit alpha-7 isoform 2; Neuronal acetylcholine receptor subunit alpha-7; neuronal acetylcholine receptor subunit alpha-7; a7 nicotinic acetylcholine receptor; alpha-7 nicotinic cholinergic receptor subunit; alpha 7 neuronal nicotinic acetylcholine receptor; cholinergic receptor, nicotinic, alpha polypeptide 7; neuronal acetylcholine receptor protein, alpha-7 chain; cholinergic receptor, nicotinic, alpha 7 (neuronal)]
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Other_gene_names
[CHRNA7; CHRNA7; NACHRA7; CHRNA7-2; NACHRA7]
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Clonality
Polyclonal
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Specificity
Recognizes Nicotinic alpha4 receptor (620-627) and the reactivity of Nicotinic alpha4 receptor is ~80%. Does not react to Nicotinic alpha3 receptor, Nicotinic alpha5 receptor, Nicotinic alpha7 receptor, Nicotinic beta2 receptor, Nicotinic beta3 receptor and Nicotinic beta4 receptor. Specific for the COOH terminal of nicotinic alpha4 receptor.
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Purity
Highly Purified Purified by precipitation, dialysis and chromatography.
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Form
Supplied as a lyophilized powder. Reconstitution with 0.1ml of 10mg/ml BSA in PBS.
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Storage_stability
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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Tested_application
Western Blot (WB), Immunocytochemistry (ICC)
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Description
The Nicotinic Receptor, alpha 4 is a α- or alpha protein sometimes glycoprotein present in blood. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
