NFkB Repressing Factor (NKRF, ITBA4, NRF)

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Description

Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.
Gene

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory

Identity

HGNC:7782
Gene

NFE2L2
Long gene name

NFE2 like bZIP transcription factor 2
Synonyms gene name
- nuclear factor (erythroid-derived 2)-like 2
- nuclear factor, erythroid 2-like 2
- nuclear factor, erythroid 2 like 2
Synonyms
- NRF2
- NRF-2
Synonyms name
- NF-E2-related factor 2
Locus

2q31.2
Discovery year

1994-03-24
Entrez gene record

4780
Pubmed identfication
- 7937919
RefSeq identity
- NM_006164
Classification
- Basic leucine zipper proteins
- MicroRNA protein coding host genes
VEGA ID

OTTHUMG00000133620

Identity

HGNC:7781
Gene

NFE2L1
Long gene name

NFE2 like bZIP transcription factor 1
Synonyms gene
- TCF11
Synonyms gene name
- nuclear factor (erythroid-derived 2)-like 1
- nuclear factor, erythroid 2-like 1
- NF-E2-related factor 1
- nuclear factor, erythroid 2 like 1
Synonyms
- NRF1
- LCR-F1
- FLJ00380
- NRF-1
Synonyms name
GenBank acession
- AK090459
Locus

17q21.32
Discovery year

1994-03-24
Entrez gene record

4779
Pubmed identfication
- 8248256
- 9501099
- 26947393
RefSeq identity
- NM_003204
Classification
- Basic leucine zipper proteins
VEGA ID

OTTHUMG00000178706