N-Cadherin/Cadherin-2/CD325 (NCAD)

• Catalog number
  MBS438963
• Price
  Please ask
• Size
  0.1 mg (With BSA & Azide at 0.2mg/mL)

• Products_type
  Antibody
• Products_short_name
  [N-Cadherin/Cadherin-2/CD325 (NCAD)]
• Products_name_syn
  [Cadherin-2 N cadherin neuronal; Cadherin-2 type 1; Cadherin-2; Calcium dependent adhesion protein neuronal; CD325; CDH2; CDHN; CDw325; N-Cadherin; NCAD]
• Other_names
  [cadherin-2 isoform 2; Cadherin-2; cadherin-2; cadherin 2; CDw325; Neural cadherin; N-cadherin; CD_antigen: CD325]
• Products_gene_name
  [NCAD]
• Products_gene_name_syn
  [CDH2; CD325]
• Other_gene_names
  [CDH2; CDH2; CDHN; NCAD; CD325; CDw325; CDHN; NCAD; N-cadherin]
• Clonality
  Monoclonal
• Clone
  [CDH2/1573]
• Reactivity
  Human, Mouse. Others not known.
• Specificity
  Recognizes a protein of ~140kDa, identified as N-Cadherin (NCAD), also known as CD325. N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. Expression of N-cadherin has been reported on a variety of normal tissues including neuronal, endothelial and muscle cells, and a subpopulation of early hematopoietic progenitor cells. Results aid in the classification of malignant non-carcinomatous neoplasms including mesotheliomas, chordomas, synovial sarcomas, malignant melanomas, epithelioid sarcomas, epithelioid angiosarcomas, clear cell sarcomas as well as serous and endometrioid tumors of the ovary have been demonstrated to be N-cadherin positive, whereas mucinous tumors are negative. Other N-cadherin-positive neoplasms include renal cell carcinomas and some variant breast tumors, including medullary breast carcinomas and sarcomatoid metaplastic breast carcinomas.
• Form
  200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Storage_stability
  Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Tested_application
  Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin

• Gene target
  N-Cadherin/Cadherin-2/CD325   NCAD  
• Gene symbol
  CDH2
• Short name
  N-Cadherin/Cadherin-2/CD325 (NCAD)
• Host
  Mouse
• Isotype
  IgG1, kappa
• Alternative name
  N-Cadherin/Cadherin-2/CD325 (NCAD)

Gene info

• Identity
  HGNC:1759
• Gene
  CDH2
• Long gene name
  cadherin 2
• Synonyms gene
  • NCAD
• Synonyms gene name
  • cadherin 2, type 1, N-cadherin (neuronal)
• Synonyms
  • CDHN
  • CD325
• Synonyms name
  • N-cadherin
• GenBank acession
  • S42303
• Locus
  18q12.1
• Discovery year
  1991-09-13
• Entrez gene record
  1000
• Pubmed identfication
  • 2384753
  • 7731968
  • 2216790
• RefSeq identity
  • NM_001792
• Classification
  • Type I classical cadherins
  • CD molecules
• VEGA ID
  OTTHUMG00000059940

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