MUC18 /CD146 / MCAM (Melanoma Cell Adhesion Molecule) Mouse Monoclonal Antibody
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Catalog numberMBS439099
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Price2013.11 USD
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Size5x0.1 mg (With BSA & Azide at 0.2mg/mL)
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Products_typeAntibody
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Products_short_name[MUC18 /CD146 / MCAM (Melanoma Cell Adhesion Molecule)]
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Products_name_syn[Cell Surface Glycoprotein MUC18, Cell Surface Glycoprotein P1H12, Gicerin, Melanoma Adhesion Molecule (MCAM), Melanoma Associated Glycoprotein MUC18, Melanoma Cell Adhesion Molecule, Melanoma-associated Antigen A32, Mel-CAM, S-endo 1 Endothelial-associated Antigen, Sendo1]
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Other_names[cell surface glycoprotein MUC18; Cell surface glycoprotein MUC18; cell surface glycoprotein MUC18; melanoma cell adhesion molecule; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; CD_antigen: CD146]
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Products_gene_name[MCAM]
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Other_gene_names[MCAM; MCAM; CD146; MUC18; MUC18]
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ClonalityMonoclonal
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Clone[C146/634]
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ReactivityHuman
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SpecificityThe human CD146 gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. CD146 is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.
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Form200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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Storage_stabilityAntibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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Tested_applicationFlow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
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Descriptioncell adhesion molecules play a role in cell growth and activation and are often identified by WB or ELISA as in the MUC18 /CD146 / MCAM (Melanoma Adhesion Molecule) Mouse Monoclonal Antibody. For cells, cell lines and tissues in culture till half confluency. Whole adhesion and interacting molecules are present in lysates used as reference for ELISA quantification of these molecules and their subunits.
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PropertiesIf you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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AboutMonoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
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TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin nameMus musculus
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French translationanticorps
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Gene target
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Gene symbolMCAM
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Short nameMUC18 /CD146 / MCAM (Melanoma Adhesion Molecule) Mouse Monoclonal Antibody
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TechniqueMouse monoclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
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HostMouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
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IsotypeIgG1, kappa
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SpeciesMouse, Mouses
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Alternative nameMUC18 /CD146 / melanoma cell adhesion molecule (Melanoma cellular Adhesion Molecule) Mouse monoclonal (antibody to-)
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Alternative techniqueantibodies, murine
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Alternative to gene targetmelanoma cell adhesion molecule, CD146 and MUC18, MCAM and IDBG-74428 and ENSG00000076706 and 102465453,4162, protein binding, nuclei, Mcam and IDBG-155835 and ENSMUSG00000032135 and 84004, MCAM and IDBG-631776 and ENSBTAG00000006835 and 281301
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Tissuecell
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Gene info
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Identity
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Gene
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Long gene namemelanoma cell adhesion molecule
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-12-18
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Entrez gene record
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Pubmed identfication
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Classification
- Ig-like cell adhesion molecule family
- C2-set domain containing
- V-set domain containing
- MicroRNA protein coding host genes
- CD molecules
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
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Tree numbers
- C04.588.531.500
- C04.619.590
- E05.598.500.496.843
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Qualifiersdiagnosis, parasitology, immunology, microbiology, diagnostic imaging, physiopathology, secondary, enzymology, etiology, mortality, epidemiology, blood, cerebrospinal fluid, chemically induced, congenital, diet therapy, drug therapy, therapy, chemistry, psychology, urine, virology, history, blood supply, classification, economics, embryology, genetics, nursing, radiotherapy, prevention & control, pathology, ultrastructure, metabolism, complications, surgery