MUC1 / EMA /CD227 (Epithelial Marker) Mouse Monoclonal Antibody

• Catalog number
  MBS438353
• Price
  Please ask
• Size
  5x0.1 mg (With BSA & Azide at 0.2mg/mL)

• Products_type
  Antibody
• Products_short_name
  [MUC1 / EMA /CD227]
• Products_name_syn
  [Breast carcinoma-associated antigen DF3, CA15-3, Carcinoma-associated mucin Episialin, Epithelial Membrane Antigen, H23AG, KL-6, MAM6, MUC-1, MUC-1/SEC, MUC-1/X, MUC1-alpha, MUC1-beta, MUC1-CT, MUC1-NT, MUC1/ZD, Mucin 1 cell surface associated, Mucin-1 subunit beta, Peanut-reactive urinary mucin, PEM, PEMT, Polymorphic epithelial mucin, PUM, Tumor-associated epithelial membrane antigen, Tumor-associated mucin]
• Other_names
  [mucin-1 isoform 2; Mucin-1; mucin-1; mucin 1, cell surface associated; Breast carcinoma-associated antigen DF3; Cancer antigen 15-3; CA 15-3]
• Products_gene_name
  [MUC1]
• Other_gene_names
  [MUC1; MUC1; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; PUM; MUC-1; CA 15-3; KL-6; PUM; PEM; EMA; MUC1-NT; MUC1-alpha; MUC1-beta]
• Clonality
  Monoclonal
• Clone
  [GP1.4 + E29]
• Reactivity
  Human
• Specificity
  In Western blotting, it recognizes proteins in MW range of 265-400kDa, identified as different glycoforms of EMA. The alpha subunit has cell adhesive properties. It can act both as an adhesion and an anti-adhesion protein. EMA may provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain, which is involved in cell signaling, through phosphorylations and protein-protein interactions. In immunohistochemical assays, it superbly stains routine formalin/paraffin carcinoma tissues. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
• Form
  200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Storage_stability
  Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Tested_application
  Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
• Properties
  If you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• French translation
  anticorps

• Gene target
  MUC1   EMA   CD227   Epithelial   Monoclonal  
• Gene symbol
  MUC1, ETFA
• Short name
  MUC1 / EMA /CD227 (Epithelial ) Mouse Monoclonal Antibody
• Technique
  Mouse monoclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, Component cell markers and DNA bp. markers are genetic markers er genes or DNA sequences with a known location on a chromosome that can be used to identify individuals or species. Protein markers in kDA. Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
• Host
  Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
• Isotype
  IgG1 and IgG2a, kappa
• Species
  Mouse, Mouses
• Alternative name
  MUC1 / EMA /CD227 (Epithelial detection labelled) Mouse monoclonal (antibody to-)
• Alternative technique
  antibodies, murine

Gene info

• Identity
  HGNC:7508
• Gene
  MUC1
• Long gene name
  mucin 1, cell surface associated
• Synonyms gene
  • PUM
  • MCKD1
• Synonyms gene name
  • mucin 1, transmembrane
  • medullary cystic kidney disease 1 (autosomal dominant)
• Synonyms
  • CD227
  • PEM
  • ADMCKD
  • ADMCKD1
  • MCKD
  • MCD
  • KL-6
  • EMA
  • Ca15-3
• Synonyms name
  • epithelial membrane antigen
• GenBank acession
  • J05581
• Locus
  1q22
• Discovery year
  1986-01-01
• Entrez gene record
  4582
• Pubmed identfication
  • 1697589
  • 23396133
• RefSeq identity
  • NM_002456
• Classification
  • CD molecules
  • Mucins
• VEGA ID
  OTTHUMG00000035681

Gene info

• Identity
  HGNC:3481
• Gene
  ETFA
• Long gene name
  electron transfer flavoprotein subunit alpha
• Synonyms gene name
  • electron-transfer-flavoprotein, alpha polypeptide
• Synonyms
  • GA2
  • EMA
  • MADD
• Synonyms name
  • glutaric aciduria II
• GenBank acession
  • J04058
• Locus
  15q24.2-q24.3
• Discovery year
  1986-01-01
• Entrez gene record
  2108
• RefSeq identity
  • NM_000126
• VEGA ID
  OTTHUMG00000172586

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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