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Products_type
Antibody
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Products_short_name
[SERPINA1 / Alpha 1 Antitrypsin]
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Products_name_syn
[Anti-SERPINA1 / Alpha 1 Antitrypsin Antibody IHC-plus; SERPINA1; A1A; A1AT; AAT; Alpha 1 Antitrypsin; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Alpha-1-antitrypsin; Alpha1AT; PRO2275; Alpha-1-antitrypsin null; PI1; Serpin A1; Human SERPINA1; Alpha 1 Antitrypsin]
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Other_names
[alpha-1-antitrypsin; Alpha-1-antitrypsin; alpha-1-antitrypsin; serpin A1; alpha-1-antiproteinase; alpha-1-antitrypsin null; alpha-1 protease inhibitor; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin; serine (or cysteine) proteinase inhibitor, clade A, member 1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1Short peptide from AAT; SPAAT]
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Products_gene_name
[SERPINA1]
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Other_gene_names
[SERPINA1; SERPINA1; PI; A1A; AAT; PI1; A1AT; PRO2275; alpha1AT; AAT; PI; SPAAT]
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Clonality
Monoclonal
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Reactivity
Human
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Specificity
Recognizes human alpha-1 antitrypsin, a serine protease inhibitor synthesized by the liver. Hereditary deficiency of this protein is associated with pulmonary emphysema and with liver disease, due to the loss of inhibition of neutrophil elastase activity. This antibody shows minimal reactivity with other serum proteins including alpha-1-antichymotrypsin
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Purity
Protein A Purified
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Form
PBS, pH 7.2, 0.09% sodium azide.
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Concentration
0.5 mg/ml
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Storage_stability
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
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Tested_application
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
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Description
The Mouse Monoclonal (IgG2a) SERPINA1 / Alpha 1 Antitrypsin is a α- or alpha protein sometimes glycoprotein present in blood.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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About
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus
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Gene target
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Gene symbol
SERPINA1
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Short name
Mouse Monoclonal (IgG2a) SERPINA1 / Alpha 1 Antitrypsin
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Technique
Mouse monoclonal, Mouse, Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
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Host
Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
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Isotype
IgG2a, IgG2a
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Species
Human, Humans, Mouses
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Alternative name
Mouse monoclonal (IgG2a) to H. sapiens serpin peptidase inhibitor, clade A (a-1 antiproteinase, antitrypsin), member 1 / a 1 Antitrypsin
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Alternative technique
murine
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Alternative to gene target
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, A1A and A1AT and AAT and alpha1AT and PI and PI1 and PRO2275, SERPINA1 and IDBG-18174 and ENSG00000197249 and 5265, identical protein binding, Extracellular, Serpina1f and IDBG-167371 and ENSMUSG00000021081 and 68348, SERPINA1 and IDBG-634001 and ENSBTAG00000018843 and 280699
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