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Products_type
Antibody
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Products_short_name
[BRCA1]
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Products_name_syn
[Anti-BRCA1 Antibody (aa341-748, clone 8F7) IHC-plus; BRCA1; BROVCA1; BRCC1; Breast cancer 1; early onset; PPP1R53; PSCP; PNCA4; RING finger protein 53; RNF53; BRCAI; Breast cancer 1 early onset; IRIS; Human BRCA1]
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Other_names
[breast cancer type 1 susceptibility protein isoform 1; Breast cancer type 1 susceptibility protein; breast cancer type 1 susceptibility protein; RING finger protein 53; Fanconi anemia, complementation group S; BRCA1/BRCA2-containing complex, subunit 1; protein phosphatase 1, regulatory subunit 53; breast and ovarian cancer susceptibility protein 1; breast and ovarian cancer sususceptibility protein 1; breast cancer 1, early onset; RING finger protein 53]
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Products_gene_name
[BRCA1]
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Other_gene_names
[BRCA1; BRCA1; IRIS; PSCP; BRCAI; BRCC1; FANCS; PNCA4; RNF53; BROVCA1; PPP1R53; RNF53]
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Clonality
Monoclonal
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Clone
[8F7]
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Reactivity
Human
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Specificity
Protein fragment expressed in E Coli corresponding to amino acids 341-748.
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Purity
Protein G Purified
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Form
PBS, pH 7.2, no preservatives.
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Concentration
1 mg/ml
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Storage_stability
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
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Tested_application
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP)
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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About
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus
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Gene target
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Gene symbol
BRCA1, BRCA1P1
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Short name
Mouse Monoclonal [clone 8F7] (IgG1) BRCA1
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Technique
Mouse monoclonal, Mouse, Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
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Host
Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
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Isotype
IgG1, IgG1
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Species
Human, Humans, Mouses
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Alternative name
Mouse monoclonal [clonality 8F7] (IgG1) to H. sapiens breast cancer 1, early onset
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Alternative technique
murine
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Alternative to gene target
breast cancer 1, early onset, BRCAI and BRCC1 and BROVCA1 and IRIS and PNCA4 and PPP1R53 and PSCP and RNF53, BRCA1 and IDBG-52172 and ENSG00000012048 and 672, androgen receptor binding, nuclei, Brca1 and IDBG-212218 and ENSMUSG00000017146 and 12189, BRCA1 and IDBG-640630 and ENSBTAG00000022520 and 353120
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Clone name
8F7
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