MOUSE ANTI SHEEP CD230 (PrPSc)

• Catalog number
  MBS212818
• Price
  Please ask
• Size
  0.25 mg

• Products_type
  Antibody
• Products_short_name
  [CD230]
• Other_names
  [major prion protein; Major prion protein; major prion protein; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); CD_antigen: CD230]
• Products_gene_name
  [CD230]
• Other_gene_names
  [PRNP; PRNP; Prp; SIP; PRPC; PRP; SIP; PrP]
• Clonality
  Monoclonal
• Clone
  [2G11]
• Specificity
  Transmissible spongiform encephalopathies (TSEs) or prion diseases are fatal infectious neurodegenerative diseases of humans and animals. These diseases are biologically unique, as they are believed by some to be transmitted by an infectious agent comprised only of protein, with no nucleic acid component. Clinically, these diseases present with motor disturbances and behavioural changes. The major pathological changes seen are neuronal loss, vacuolation (spongiform change), proliferation and branching of glial cells, astrocytic proliferation and accumulation of the prion protein PrPSc, which can form amyloid plaques. CD230. also known as the prion protein (PrP) exists in two alternate forms; a normal cellular form (PrPc) and a disease-associated form (PrPSc).The normal and pathological forms of the prion protein have identical amino acid sequences and differ only in their folded tertiary structure and biochemical properties. This item is specific for PrPSc. This clone does not appear to immunostain the normall cellular PrP expressed in heathly sheep tissue sections resulting in specific labelling of ovine PrPSc. This antibody was raised against a synthetic peptide (146-R154R171-182) of the ovine PrP peptide and specificially recognises the R151-R159 sequence.
• Form
  Purified Purified IgG - liquid
• Concentration
  IgG concentration 1.0 mg/ml
• Storage_stability
  Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
• Tested_application
  ELISA (EIA), Immunohistology Paraffin*
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus

• Gene target
  CD230   PrPSc  
• Gene symbol
  PRNP
• Short name
  MOUSE ANTI CD230 (PrPSc)
• Technique
  Mouse, anti, antibody to, mouses
• Host
  Mouse
• Isotype
  IgG2a
• Species
  Sheep, Mouses, The sheep (Ovis aries) ELISAs are detecting sheep proteins and antigens. Some epitopes will also recognize goat proteins. Sheep and goats are also used to produce polyclonals. An adult female sheep is referred to as a ewe a male as a ram, a castrated male as a wether, and a younger sheep as a lamb. Sheeps
• Alternative name
  MOUSE antibody to ovine CD230 (PrPSc)
• Alternative technique
  murine, antibodies

Gene info

• Identity
  HGNC:9449
• Gene
  PRNP
• Long gene name
  prion protein
• Synonyms gene
  • PRIP
  • GSS
  • CJD
• Synonyms gene name
  • prion protein (p27-30)
• Synonyms
  • CD230
  • PRP
  • AltPrP
• Synonyms name
  • Creutzfeldt-Jakob disease
  • Gerstmann-Strausler-Scheinker syndrome
  • fatal familial insomnia
  • p27-30
• GenBank acession
  • M13899
• Locus
  20p13
• Discovery year
  1986-01-01
• Entrez gene record
  5621
• RefSeq identity
  • NM_000311
• Classification
  • CD molecules
• VEGA ID
  OTTHUMG00000031786
• Locus Specific Databases
  • Prion Protein/CJD database

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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