Melanoma Marker (MART-1 + gp100 + Tyrosinase) Mouse Monoclonal Antibody

• Catalog number
  MBS438157
• Price
  Please ask
• Size
  0.02 mg (With BSA & Azide at 0.2mg/mL)

• Products_type
  Antibody
• Products_short_name
  [Melanoma Marker]
• Products_name_syn
  [Melanoma antigen recognized by T-cells 1 (MART-1), MLAN-A; TYR; PMEL17]
• Other_names
  [melanoma antigen recognized by T-cells 1; Melanoma antigen recognized by T-cells 1; melanoma antigen recognized by T-cells 1; melan-A; Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A]
• Other_gene_names
  [MLANA; MLANA; MART1; MART-1; MART1; MART-1]
• Clonality
  Monoclonal
• Clone
  [M2-7C10 + M2-9E3 + HMB45 + T311]
• Reactivity
  Human. Others not tested
• Specificity
  This antibody cocktail recognizes three melanoma-specific proteins, which include MART-1, Tyrosinase and gp100. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Function of gp100 is not known but it is reported to be a useful marker for melanocytes and melanomas. This cocktail of three markers is designed for extremely sensitive labeling of formalin-fixed, paraffin-embedded melanomas and other tumors showing melanocytic differentiation.
• Form
  200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Storage_stability
  Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Tested_application
  Immunohistochemistry (IHC) Formalin
• Properties
  If you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• French translation
  anticorps

• Gene target
  Melanoma   MART-1   gp100   Tyrosinase   Monoclonal  
• Gene symbol
  MLANA, RTL1, HHAT, IGHVII-1-1, MIR1-1, TRUND-NNN8-1, SEPTIN4, TRUND-NNN7-1, IGKV1OR2-1, MIR101-1
• Short name
  Melanoma (MART-1 + gp100 + Tyrosinase) Mouse Monoclonal Antibody
• Technique
  Mouse monoclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, Component cell markers and DNA bp. markers are genetic markers er genes or DNA sequences with a known location on a chromosome that can be used to identify individuals or species. Protein markers in kDA. Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
• Host
  Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
• Isotype
  IgG1, IgG2a & IgG2b, kappa
• Species
  Mouse, Mouses
• Alternative name
  Melanoma detection labelled (MART-1 + gp100 + Tyrosinase) Mouse monoclonal (antibody to-)
• Alternative technique
  antibodies, murine

Gene info

• Identity
  HGNC:7124
• Gene
  MLANA
• Long gene name
  melan-A
• Synonyms
  • MART1
  • MART-1
• Locus
  9p24.1
• Discovery year
  1994-08-29
• Entrez gene record
  2315
• Pubmed identfication
  • 12191019
• VEGA ID
  OTTHUMG00000019510

Gene info

• Identity
  HGNC:14665
• Gene
  RTL1
• Long gene name
  retrotransposon Gag like 1
• Synonyms gene name
  • retrotransposon-like 1
• Synonyms
  • PEG11
  • MART1
  • Mar1
  • SIRH2
  • HUR1
• Synonyms name
  • Sushi-Ichi retrotransposon homolog 2
  • mammalian retrotransposon-derived 1
  • paternally expressed 11
• Locus
  14q32.2
• Discovery year
  2006-02-27
• Entrez gene record
  388015
• Pubmed identfication
  • 16155747
  • 15854907
  • 12796779
• RefSeq identity
  • NM_001134888
• Classification
  • Retrotransposon Gag like
• VEGA ID
  OTTHUMG00000167573
• Locus Specific Databases
  • LRG_1059

Gene info

• Identity
  HGNC:18270
• Gene
  HHAT
• Long gene name
  hedgehog acyltransferase
• Synonyms
  • FLJ10724
  • MART-2
  • MART2
  • Skn
  • ski
  • rasp
  • sit
  • GUP2
• Synonyms name
  • protein-cysteine N-palmitoyltransferase HHAT
• GenBank acession
  • AK001586
• Locus
  1q32.2
• Discovery year
  2004-09-15
• Entrez gene record
  55733
• Pubmed identfication
  • 11160356
• RefSeq identity
  • NM_018194
• Classification
  • Membrane bound O-acyltransferases
• VEGA ID
  OTTHUMG00000036447

Gene info

• Identity
  HGNC:5670
• Gene
  IGHVII-1-1
• Long gene name
  immunoglobulin heavy variable (II)-1-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable (II)-1-1
  • immunoglobulin heavy variable (II)-1-1 pseudogene
• Synonyms
  • IGHV(II)-1-1
• GenBank acession
  • AB019441
• Locus
  14q32.33
• Discovery year
  2000-04-17
• Entrez gene record
  28377
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152325

Gene info

• Identity
  HGNC:31499
• Gene
  MIR1-1
• Long gene name
  microRNA 1-1
• Synonyms gene
  • MIRN1-1
• Synonyms
  • hsa-mir-1-1
• Locus
  20q13.33
• Discovery year
  2004-04-23
• Entrez gene record
  406904
• RefSeq identity
  • NR_029780
• Classification
  • MicroRNA MIR1/206 family

Gene info

• Identity
  HGNC:50820
• Gene
  TRUND-NNN8-1
• Long gene name
  tRNA-undetermined (NNN) 8-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 8-1
• GenBank acession
  • HG984097
• Locus
  1
• Discovery year
  2014-06-20
• Entrez gene record
  103482528
• Pubmed identfication
  • 18984615

Gene info

• Identity
  HGNC:9165
• Gene
  SEPTIN4
• Long gene name
  septin 4
• Synonyms gene
  • PNUTL2
  • C17orf47
  • SEPT4
• Synonyms gene name
  • peanut-like 2 (Drosophila)
  • chromosome 17 open reading frame 47
• Synonyms
  • H5
  • CE5B3
  • hucep-7
  • ARTS
  • hCDCREL-2
  • MART
  • FLJ40121
• Synonyms name
  • bradeoin
  • septin-M
• GenBank acession
  • AF073312
• Locus
  17q22
• Discovery year
  1998-07-15
• Entrez gene record
  5414
• Pubmed identfication
  • 9889007
• RefSeq identity
  • NM_080417
• Classification
  • Septins
• VEGA ID
  OTTHUMG00000179243

Gene info

• Identity
  HGNC:50819
• Gene
  TRUND-NNN7-1
• Long gene name
  tRNA-undetermined (NNN) 7-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 7-1
• GenBank acession
  • HG984096
• Locus
  1
• Discovery year
  2014-06-20
• Entrez gene record
  103482531
• Pubmed identfication
  • 18984615

Gene info

• Identity
  HGNC:5760
• Gene
  IGKV1OR2-1
• Long gene name
  immunoglobulin kappa variable 1/OR2-1 (pseudogene)
• Synonyms gene
  • IGKVPZ1
  • IGKV1OR-1
• Synonyms gene name
  • immunoglobulin kappa variable 1/OR-1
  • immunoglobulin kappa variable 1/OR-1 pseudogene
  • immunoglobulin kappa variable 1/OR-1 (pseudogene)
• Synonyms
  • IGKV1/OR-1
  • IGKV1/OR2-1
• GenBank acession
  • Z12367
• Locus
  2p11.1
• Discovery year
  2000-04-18
• Entrez gene record
  3531
• Pubmed identfication
  • 2853098
• Classification
  • Immunoglobulin kappa (IGK) orphons
• VEGA ID
  OTTHUMG00000155081

Gene info

• Identity
  HGNC:31488
• Gene
  MIR101-1
• Long gene name
  microRNA 101-1
• Synonyms gene
  • MIRN101-1
• Synonyms
  • hsa-mir-101-1
• Locus
  1p31.3
• Discovery year
  2004-04-23
• Entrez gene record
  406893
• RefSeq identity
  • NR_029516
• Classification
  • MicroRNA MIR101 family

MeSH Data

• Name
  Mammary Neoplasms, Experimental
• Concept
  Scope note: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
• Tree numbers
  • C04.588.531.500
  • C04.619.590
  • E05.598.500.496.843
• Qualifiers
  diagnosis, parasitology, immunology, microbiology, diagnostic imaging, physiopathology, secondary, enzymology, etiology, mortality, epidemiology, blood, cerebrospinal fluid, chemically induced, congenital, diet therapy, drug therapy, therapy, chemistry, psychology, urine, virology, history, blood supply, classification, economics, embryology, genetics, nursing, radiotherapy, prevention & control, pathology, ultrastructure, metabolism, complications, surgery

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