MCAM (Melanoma Cell Adhesion Molecule) (Biotin)

• Catalog number
  MBS603289
• Price
  Please ask
• Size
  5x0.5 mg

• Products_type
  Antibody
• Products_short_name
  [MCAM]
• Products_name_syn
  [Anti -MCAM (Melanoma Cell Adhesion Molecule) (Biotin)]
• Other_names
  [Melanoma cell adhesion molecule; Cell surface glycoprotein MUC18; cell surface glycoprotein MUC18; Gicerin; OTTHUMP00000232151; melanoma adhesion molecule; cell surface glycoprotein P1H12; melanoma-associated antigen A32; melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; melanoma cell adhesion molecule; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen]
• Other_gene_names
  [MCAM; MCAM; CD146; MUC18; MUC18]
• Clonality
  Monoclonal
• Clone
  [5K96]
• Reactivity
  Chicken
• Specificity
  Recognizes chicken MCAM, Mr 98kD (protein core ~84kD).
• Purity
  Purified Purified.
• Form
  Supplied as a liquid in PBS, 0.1% sodium azide. Labeled with Biotin.
• Storage_stability
  May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50?glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
• Tested_application
  Immunoprecipitation (IP), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
• Description
  cell adhesion molecules play a role in cell growth and activation and are often identified by WB or ELISA as in the MCAM (Melanoma Adhesion Molecule) ( ). For cells, cell lines and tissues in culture till half confluency. Whole adhesion and interacting molecules are  present in lysates used as reference for ELISA quantification of these molecules and their subunits.
• Properties
  Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6.
• Conjugation
  Biotinylated

• Gene target
  MCAM   Melanoma   Adhesion   Molecule  
• Gene symbol
  MCAM
• Short name
  MCAM (Melanoma Adhesion Molecule) ( )
• Host
  Mouse
• Isotype
  IgG2b,k
• Label
  Biotin
• Alternative name
  melanoma cell adhesion molecule (Melanoma cellular Adhesion Molecule) (biotinilated)
• Alternative to gene target
  melanoma cell adhesion molecule, CD146 and MUC18, MCAM and IDBG-74428 and ENSG00000076706 and 102465453,4162, protein binding, nuclei, Mcam and IDBG-155835 and ENSMUSG00000032135 and 84004, MCAM and IDBG-631776 and ENSBTAG00000006835 and 281301
• Tissue
  cell

Gene info

• Identity
  HGNC:6934
• Gene
  MCAM
• Long gene name
  melanoma cell adhesion molecule
• Synonyms
  • MUC18
  • CD146
  • MelCAM
  • METCAM
  • HEMCAM
• Synonyms name
  • Gicerin
• GenBank acession
  • X68264
• Locus
  11q23.3
• Discovery year
  1995-12-18
• Entrez gene record
  4162
• Pubmed identfication
  • 2602381
  • 10702685
  • 19229070
• Classification
  • Ig-like cell adhesion molecule family
  • C2-set domain containing
  • V-set domain containing
  • MicroRNA protein coding host genes
  • CD molecules
• VEGA ID
  OTTHUMG00000166197

MeSH Data

• Name
  Mammary Neoplasms, Experimental
• Concept
  Scope note: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
• Tree numbers
  • C04.588.531.500
  • C04.619.590
  • E05.598.500.496.843
• Qualifiers
  diagnosis, parasitology, immunology, microbiology, diagnostic imaging, physiopathology, secondary, enzymology, etiology, mortality, epidemiology, blood, cerebrospinal fluid, chemically induced, congenital, diet therapy, drug therapy, therapy, chemistry, psychology, urine, virology, history, blood supply, classification, economics, embryology, genetics, nursing, radiotherapy, prevention & control, pathology, ultrastructure, metabolism, complications, surgery

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