-
Products_type
Antibody
-
Products_short_name
[MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1)]
-
Products_name_syn
[MEKK1; MEK Kinase 1; MEKK; SRXY6; MAPKKK1]
-
Other_names
[mitogen-activated protein kinase kinase kinase 1; Mitogen-activated protein kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase 1; MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1]
-
Products_gene_name
[MAP3K1]
-
Other_gene_names
[MAP3K1; MAP3K1; MEKK; MEKK1; SRXY6; MEKK 1; MAPKKK1; MAPKKK1; MEKK; MEKK1; MEK kinase 1; MEKK 1]
-
Clonality
Monoclonal
-
Clone
[2F6]
-
Reactivity
Human. Others not known
-
Specificity
Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli, including growth factors. The MEK kinases (also designated MAP kinase kinase kinases, MKKKs, MAP3Ks or MEKKs) phosphorylate and thereby activate the MEKs (also called MAP kinase kinases or MKKs), including ERK, JNK and p38. These activated MEKs in turn phosphorylate and activate the MAP kinases. The MEK kinases include Raf-1, Raf-B, Mos, MEK kinase-1, MEK kinase-2, MEK kinase-3, MEK kinase-4 and ASK 1 (MEK kinase- 5). MEK kinase-1 activates the ERK and c-Jun NH2-terminal kinase (JNK) pathways by phosphorylation of MAP2K1 and MAP2K4, and also activates the central protein kinases of the NF-kB pathway, CHUK and IKBKB. Additionally, MEK kinase-1 uses an E3 ligase through its PHD domain, a RING-finger-like structure, to target proteins for degradation through ubiquitination.
-
Form
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
-
Storage_stability
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
-
Tested_application
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin
-
Properties
If you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
About
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
-
Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
-
Latin name
Mus musculus
-
French translation
anticorps
-
Gene target
-
Gene symbol
MAP3K1
-
Short name
MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) Mouse Monoclonal Antibody
-
Technique
Mouse monoclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
-
Host
Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
-
Isotype
IgG2a, kappa
-
Species
Mouse, Mouses
-
Alternative name
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase (Mitogen-Activated Protein phosphorylation catalyst phosphorylation catalyst phosphorylation catalyst 1) Mouse monoclonal (antibody to-)
-
Alternative technique
antibodies, murine
-
Alternative to gene target
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase, MAPKKK1 and MEKK and MEKK 1 and MEKK1 and SRXY6, MAP3K1 and IDBG-22000 and ENSG00000095015 and 4214, transferase activity, Cytoplasm, Map3k1 and IDBG-182342 and ENSMUSG00000021754 and 26401, MAP3K1 and IDBG-629015 and ENSBTAG00000013790 and 523962
-
