Lipopolysaccharide-induced CXC Chemokine, Recombinant, Mouse (LPS-induced CXC Chemokine, LIX, Chemokine (C-X-C Motif) Ligand 5, C-X-C Motif Chemokine 5, CXCL5, Cytokine LIX, AMCF-II, ENA-78, GCP-2, Small-inducible Cytokine B5, Scyb5)[Lipopolysaccharide-induced CXC Chemokine]
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Catalog number
MBS650752
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Price
Please ask
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Size
NA
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Products_type
Recombinant Protein
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Description
Chemokines, chemokine receptors, ligands , motif chemokines and cytokines are supplied by MyBioSource in 1. Cytokines and Chemokines are chemotaxis related small proteins between 5 to 20 kDa. Induced protein genes, factors or kinases, increase the production of (an enzyme or other protein) at the level of genetic transcription. FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
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Gene
Bacterial pathogen lipopolysaccharides (LPS) are the major outer surface membrane components present in almost all Gram-negative bacteria and act as extremely strong stimulators of innate or natural immunity in diverse eukaryotic species ranging from insects to humans. LPS consist of a poly- or oligosaccharide region that is anchored in the outer bacterial membrane by a specific carbohydrate lipid moiety termed lipid A. The lipid A component is the primary immunostimulatory center of LPS. With respect to immunoactivation in mammalian systems, the classical group of strongly agonistic (highly endotoxin) forms of LPS has been shown to be comprised of a rather similar set of lipid A types. In addition, several natural or derivative lipid A structures have been identified that display comparatively low or even no immunostimulation for a given mammalian species. Some members of the latter more heterogeneous group are capable of antagonizing the effects of strongly stimulatory LPS/lipid A forms. Agonistic forms of LPS or lipid A trigger numerous physiological immunostimulatory effects in mammalian organisms, but--in higher doses--can also lead to pathological reactions such as the induction of septic shock. Cells of the myeloid lineage have been shown to be the primary cellular sensors for LPS in the mammalian immune system. During the past decade, enormous progress has been obtained in the elucidation of the central LPS/lipid A recognition and signaling system in mammalian phagocytes. According to the current model, the specific cellular recognition of agonistic LPS/lipid A is initialized by the combined extracellular actions of LPS binding protein (LBP), the membrane-bound or soluble forms of CD14 and the newly identified Toll-like receptor 4 (TLR4)*MD-2 complex, leading to the rapid activation of an intracellular signaling network that is highly homologous to the signaling systems of IL-1 and IL-18. The elucidation of structure-activity correlations in LPS and lipid A has not only contributed to a molecular understanding of both immunostimulatory and toxic septic processes, but has also re-animated the development of new pharmacological and immuno-stimulatory strategies for the prevention and therapy of infectious and malignant diseases.
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
P4HA2, SMC4, GZMH, MYB, PCK1, SFTPC, VCX3B, MAF, RFX1, EGR4
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Short name
Lipopolysaccharide- CXC Chemokine, Recombinant, Mouse (LPS- CXC Chemokine, LIX, Chemokine (C-X-C Motif) Ligand 5, C-X-C Motif Chemokine 5, CXCL5, Cytokine LIX, AMCF-II, ENA-78, GCP-2, - Cytokine B5, Scyb5)[Lipopolysaccharide- CXC Chemokine]
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Technique
Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. MyBioSource advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Host
mouse
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Species
Mouse, Mouses
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Alternative name
Lipopolysaccharide-induced CXC Chemokine, Rec., Mouse (LPS-induced CXC Chemokine, LIX, Chemokine (C-X-C Motif) Ligand 5, C-X-C Motif Chemokine 5, chemokine (C-X-C motif) ligand 5, Cytokine LIX, AMCF-II, ENA-78, GCP-2, Small-inducible Cytokine B5, Scyb5)[Lipopolysaccharide-induced CXC Chemokine]
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Alternative technique
rec, murine
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Alternative to gene target
chemokine (C-X-C motif) ligand 5, ENA-78 and SCYB5, CXCL5 and IDBG-24181 and ENSG00000163735 and 6374, chemokine activity, Extracellular
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Gene info
Gene info
Gene info
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Identity
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Gene
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Long gene name
granzyme H
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Synonyms gene
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Synonyms gene name
- granzyme H (cathepsin G-like 2, protein h-CCPX)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1990-04-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Granule associated serine proteases of immune defence
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VEGA ID
Gene info
Gene info
Gene info
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Identity
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Gene
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Long gene name
surfactant protein C
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Synonyms gene
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Synonyms gene name
- surfactant, pulmonary-associated protein C
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Synonyms
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Synonyms name
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Locus
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Discovery year
1988-05-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- BRICHOS domain containing
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VEGA ID
Gene info
Gene info
Gene info
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Identity
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Gene
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Long gene name
regulatory factor X1
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Synonyms gene name
- regulatory factor X, 1 (influences HLA class II expression)
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Synonyms
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Synonyms name
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Locus
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Discovery year
1991-11-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Regulatory factor X family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
early growth response 4
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Synonyms
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Locus
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Discovery year
1992-07-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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