LIFR (Leukemia Inhibitory Factor Receptor, LIF Receptor, LIF-R, CD118)

• Catalog number
  MBS632405
• Price
  Please ask
• Size
  0.1 mg

• Products_type
  Antibody
• Products_short_name
  [LIFR]
• Products_name_syn
  [Anti -LIFR (Leukemia Inhibitory Factor Receptor, LIF Receptor, LIF-R, CD118)]
• Other_names
  [leukemia inhibitory factor receptor; Leukemia inhibitory factor receptor; leukemia inhibitory factor receptor; LIF receptor; CD118 antigen; OTTHUMP00000161786; OTTHUMP00000221308; leukemia inhibitory factor receptor alpha]
• Other_gene_names
  [LIFR; SWS; SJS2; STWS; CD118; LIF-R; FLJ98106; FLJ99923]
• Clonality
  Monoclonal
• Clone
  [4A10]
• Reactivity
  Human
• Specificity
  Recognizes human LIFR.
• Purity
  Purified Purified.
• Form
  Supplied as a liquid in PBS, pH 7.2.
• Storage_stability
  May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Tested_application
  ELISA (EL/EIA)
• Description
  Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

• Gene target
  LIFR   Leukemia   Inhibitory   Factor   Receptor   LIF   Receptor   LIF-R   CD118  
• Gene symbol
  LIFR, LIF-AS1, LIFR-AS1, LIF-AS2, LIF, RRAS, DAD1P1, HNRNPR, CLDN4, MC1R
• Short name
  LIFR (Leukemia Inhibitory Factor Receptor, LIF Receptor, LIF-R, CD118)
• Host
  Mouse
• Isotype
  IgG2a, k
• Alternative name
  leukemia inhibitory factor receptor alpha (Leukemia Inhibitory Factor Receptor, leukemia inhibitory factor Receptor, leukemia inhibitory factor-R, CD118)
• Alternative to gene target
  leukemia inhibitory factor, CDF and DIA and HILDA and MLPLI, LIF and IDBG-3968 and ENSG00000128342 and 3976, growth factor activity, Extracellular, Lif and IDBG-142317 and ENSMUSG00000034394 and 16878, LIF and IDBG-636335 and ENSBTAG00000007424 and 280840
• Virus
  leukemia

Gene info

• Identity
  HGNC:6597
• Gene
  LIFR
• Long gene name
  LIF receptor subunit alpha
• Synonyms gene name
  • leukemia inhibitory factor receptor
  • leukemia inhibitory factor receptor alpha
  • LIF receptor alpha
• Synonyms
  • CD118
• GenBank acession
  • X61615
• Locus
  5p13.1
• Discovery year
  1992-08-24
• Entrez gene record
  3977
• Pubmed identfication
  • 1915266
• RefSeq identity
  • NM_002310
• Classification
  • Fibronectin type III domain containing
  • CD molecules
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000131138

Gene info

• Identity
  HGNC:53473
• Gene
  LIF-AS1
• Long gene name
  LIF antisense RNA 1
• Synonyms
  • Lnc-LIF-AS
• Locus
  22q12.2
• Discovery year
  2017-04-28
• Pubmed identfication
  • 28391028
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:43600
• Gene
  LIFR-AS1
• Long gene name
  LIFR antisense RNA 1
• Synonyms gene name
  • LIFR antisense RNA 1 (non-protein coding)
• GenBank acession
  • BC038371
• Locus
  5p13.1
• Discovery year
  2011-11-23
• Entrez gene record
  100506495
• Pubmed identfication
  • 26725846
  • 29807108
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000162109

Gene info

• Identity
  HGNC:28298
• Gene
  LIF-AS2
• Long gene name
  LIF antisense RNA 2
• Locus
  22q12.2
• Discovery year
  2020-10-07
• Entrez gene record
  91370
• RefSeq identity
  • NR_148946
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:6596
• Gene
  LIF
• Long gene name
  LIF interleukin 6 family cytokine
• Synonyms gene name
  • leukemia inhibitory factor
  • LIF, interleukin 6 family cytokine
• Synonyms
  • CDF
  • DIA
  • HILDA
• Synonyms name
  • differentiation inhibitory activity
  • differentiation-inducing factor
  • hepatocyte-stimulating factor III
  • cholinergic differentiation factor
  • human interleukin in DA cells
• Locus
  22q12.2
• Discovery year
  1989-06-11
• Entrez gene record
  3976
• Pubmed identfication
  • 1714745
  • 8058719
• RefSeq identity
  • NM_002309
• Classification
  • Receptor ligands
  • Interleukin 6 type cytokine family
• VEGA ID
  OTTHUMG00000150910
• Locus Specific Databases
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database

Gene info

• Identity
  HGNC:10447
• Gene
  RRAS
• Long gene name
  RAS related
• Synonyms gene name
  • related RAS viral (r-ras) oncogene homolog
• Synonyms
  • R-Ras
• Synonyms name
  • Oncogene RRAS
• Locus
  19q13.33
• Discovery year
  2001-06-22
• Entrez gene record
  6237
• Pubmed identfication
  • 3098437
• RefSeq identity
  • NM_006270
• Classification
  • RAS type GTPase family
• VEGA ID
  OTTHUMG00000183247

Gene info

• Identity
  HGNC:18295
• Gene
  DAD1P1
• Long gene name
  defender against cell death 1 pseudogene 1
• Synonyms gene
  • DAD1L
• Synonyms gene name
  • defender against cell death 1-like
• Synonyms
  • DAD-R
• Locus
  12p12.1
• Discovery year
  2007-07-26
• Entrez gene record
  56286
• Pubmed identfication
  • 10812081
  • 11912161
• RefSeq identity
  • NR_024064

Gene info

• Identity
  HGNC:5047
• Gene
  HNRNPR
• Long gene name
  heterogeneous nuclear ribonucleoprotein R
• Synonyms gene
  • HNRPR
• Synonyms
  • hnRNP-R
• GenBank acession
  • AF000364
• Locus
  1p36.12
• Discovery year
  1999-06-11
• Entrez gene record
  10236
• Pubmed identfication
  • 9421497
• RefSeq identity
  • NM_005826
• Classification
  • Heterogeneous nuclear ribonucleoproteins
  • RNA binding motif containing
• VEGA ID
  OTTHUMG00000003224

Gene info

• Identity
  HGNC:2046
• Gene
  CLDN4
• Long gene name
  claudin 4
• Synonyms gene
  • CPETR
  • CPETR1
• Synonyms
  • CPE-R
  • WBSCR8
  • hCPE-R
• Synonyms name
  • Clostridium perfringens enterotoxin receptor 1
  • Williams-Beuren syndrome chromosomal region 8 protein
• GenBank acession
  • AB000712
• Locus
  7q11.23
• Discovery year
  1998-04-22
• Entrez gene record
  1364
• Pubmed identfication
  • 9334247
  • 9892664
• RefSeq identity
  • NM_001305
• Classification
  • Claudins
• VEGA ID
  OTTHUMG00000023425

Gene info

• Identity
  HGNC:6929
• Gene
  MC1R
• Long gene name
  melanocortin 1 receptor
• Synonyms gene name
  • melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
• Synonyms
  • MSH-R
• Synonyms name
  • alpha melanocyte stimulating hormone receptor
• Locus
  16q24.3
• Discovery year
  1993-07-27
• Entrez gene record
  4157
• Pubmed identfication
  • 8458079
• RefSeq identity
  • NM_002386
• Classification
  • Melanocortin receptors
• VEGA ID
  OTTHUMG00000171163

MeSH Data

• Name
  Leukemia, Experimental
• Concept
  Scope note: Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.
• Tree numbers
  • C04.557.337.372
  • C04.619.531
  • E05.598.500.496.500
• Qualifiers
  diagnosis, parasitology, immunology, microbiology, diagnostic imaging, physiopathology, rehabilitation, enzymology, etiology, mortality, epidemiology, blood, cerebrospinal fluid, chemically induced, congenital, diet therapy, drug therapy, therapy, psychology, urine, virology, history, classification, economics, embryology, genetics, nursing, radiotherapy, ethnology, prevention & control, pathology, metabolism, complications, surgery

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