-
Products_type
Antibody
-
Products_short_name
[IGFLR1]
-
Products_name_syn
[Anti -IGFLR1 (IGF-like Family Receptor 1, Transmembrane Protein 149, TMEM149, U2 Small Nuclear RNA Auxiliary Factor 1-like 4, U2AF1L4)]
-
Other_names
[IGF-like family receptor 1; IGF-like family receptor 1; IGF-like family receptor 1; transmembrane protein 149; U2 small nuclear RNA auxiliary factor 1-like 4; U2(RNU2) small nuclear RNA auxiliary factor 1-like 4; IGF-like family receptor 1; Transmembrane protein 149; U2 small nuclear RNA auxiliary factor 1-like 4]
-
Other_gene_names
[IGFLR1; IGFLR1; TMEM149; U2AF1L4; TMEM149; U2AF1L4]
-
Clonality
Polyclonal
-
Reactivity
Human
-
Specificity
Recognizes human U2AF1L4.
-
Purity
Affinity Purified Purified by Protein A affinity chromatography.
-
Form
Supplied as a liquid in PBS, pH 7.2.
-
Storage_stability
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
-
Tested_application
Western Blot (WB), Immunofluorescence (IF)
-
Description
Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. IGF-I, IGF-II, insulin-like growth factors -1 and -2 are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
