Hypoxia Inducible Factor 1 alpha (Hypoxia Inducible Factor 1 alpha Subunit Basic Helix-loop-helix Transcription Factor, HIF1A, HIF-1 alpha, HIF-1A, HIF1-alpha, ARNT Interacting Protein, Basic Helix-loop-helix PAS Protein MOP1, Member of PAS Protein 1, Mem
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Catalog numberMBS620726
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PricePlease ask
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Size0.1 mL
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Products_typeAntibody
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Products_short_name[Hypoxia Inducible Factor 1 alpha]
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Products_name_syn[Anti -Hypoxia Inducible Factor 1 alpha (Hypoxia Inducible Factor 1 alpha Subunit Basic Helix-loop-helix Transcription Factor, HIF1A, HIF-1 alpha, HIF-1A, HIF1-alpha, ARNT Interacting Protein, Basic Helix-loop-helix PAS Protein MOP1, Member of PAS Protein 1, Mem]
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Other_names[hypoxia-inducible factor 1-alpha isoform 1; Hypoxia-inducible factor 1-alpha; hypoxia-inducible factor 1-alpha; HIF-1-alpha; OTTHUMP00000179061; OTTHUMP00000179062; OTTHUMP00000179063; member of PAS protein 1; ARNT interacting protein; ARNT-interacting protein; member of PAS superfamily 1; PAS domain-containing protein 8; basic-helix-loop-helix-PAS protein MOP1; class E basic helix-loop-helix protein 78; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78; bHLHe78; Member of PAS protein 1; PAS domain-containing protein 8]
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Other_gene_names[HIF1A; HIF1A; HIF1; MOP1; PASD8; bHLHe78; HIF-1alpha; HIF1-ALPHA; BHLHE78; MOP1; PASD8]
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ClonalityPolyclonal
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ReactivityHuman, Monkey, Mouse, Rat
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SpecificityRecognizes mouse HIF-1 alpha. Species Crossreactivity: rat, human, primate. Antibody has been tested in Western Blot, recognizing a band in hypoxic samples at ~115kD. Rat retina and brain cortex have been tested. Rat brain cortex is a bit dirty but this antibody does detect upregulation of HIF-1 alpha in hypoxic samples.
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PurityAffinity Purified Purified by immunoaffinity chromatography.
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FormSupplied as a liquid in PBS. No preservatives added. Labeled with HRP.
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Storage_stabilityMay be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Labeled with horseradish peroxidase (HRP). Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. HRP conjugates are sensitive to light.
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Tested_applicationWestern Blot (WB), Immunohistochemistry (IHC)
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DescriptionThe Hypoxia Factor 1 alpha (Hypoxia Factor 1 alpha Subunit Helix-loop-helix Transcription Factor, HIF1A, HIF-1 alpha, HIF-1A, HIF1-alpha, ARNT Interacting Protein, Helix-loop-helix PAS Protein MOP1, Member of PAS Protein 1, Mem is a α- or alpha protein sometimes glycoprotein present in blood. Basic proteins pH>7 are often produced recombinant and shouldn’t be precipitated by formic acid buffer. Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. The activation of transcription factor subunits is the first step of gene expression, in which a particular segment of DNA is copied into RNA (mRNA) by the enzyme RNA polymerases. Transcription factors, unites and elongations can be RNA and DNA nucleic acids, base pairs of nucleotides . Converting from DNA to RNA is made by enzymatic reactions. During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, anti-parallel RNA strand called a primary transcript. Transcriptions are key functions in signal transduction pathways. Signaling ligand binding transcription factors play an important role in transduction cascades.
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Gene target
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Gene symbolHIF1A, ARNT, HIF1A-AS1, HIF1A-AS2, HIF1A-AS3, SETD2, NPAS4, IGKV2OR2-1, POU2F3, IGHD1OR15-1A
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Short nameHypoxia Factor 1 alpha (Hypoxia Factor 1 alpha Subunit Helix-loop-helix Transcription Factor, HIF1A, HIF-1 alpha, HIF-1A, HIF1-alpha, ARNT Interacting Protein, Helix-loop-helix PAS Protein MOP1, Member of PAS Protein 1, Mem
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HostRabbit
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IsotypeIgG
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Alternative nameHypoxia Inducible Factor 1 a (Hypoxia Inducible Factor 1 a functionnal sequence Basic Helix-loop-helix Transcription Factor, hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), HIF-1 a, HIF-1A, HIF1-a, ARNT Interacting Protein, Basic Helix-loop-helix PAS Protein MOP1, Member on PAS Protein 1, Mem
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Alternative to gene targethypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), bHLHe78 and HIF-1A and HIF-1alpha and HIF1 and HIF1-ALPHA and MOP1 and PASD8, HIF1A and IDBG-8510 and ENSG00000100644 and 3091, Hsp90 protein binding, nuclei, Hif1a and IDBG-148620 and ENSMUSG00000021109 and 15251, HIF1A and IDBG-646757 and ENSBTAG00000020935 and 281814
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Gene info
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Identity
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Gene
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Long gene namehypoxia inducible factor 1 subunit alpha
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Synonyms gene name
- hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-03-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Basic helix-loop-helix proteins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namearyl hydrocarbon receptor nuclear translocator
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Synonyms
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GenBank acession
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Locus
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Discovery year1990-01-22
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Entrez gene record
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Classification
- Basic helix-loop-helix proteins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameHIF1A antisense RNA 1
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Synonyms gene name
- HIF1A antisense RNA 1 (non-protein coding)
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Synonyms
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GenBank acession
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Locus
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Discovery year2011-09-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Antisense RNAs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameHIF1A antisense RNA 2
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Synonyms gene name
- HIF1A antisense RNA 2 (non-protein coding)
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Synonyms
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Locus
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Discovery year2011-09-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Antisense RNAs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameHIF1A antisense RNA 3
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Locus
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Discovery year2019-05-01
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Entrez gene record
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RefSeq identity
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Classification
- Antisense RNAs
Gene info
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Identity
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Gene
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Long gene nameSET domain containing 2, histone lysine methyltransferase
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Synonyms gene name
- SET domain containing 2
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Synonyms
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GenBank acession
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Locus
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Discovery year2006-02-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- SET domain containing
- Lysine methyltransferases
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameneuronal PAS domain protein 4
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Synonyms
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GenBank acession
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Locus
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Discovery year2005-09-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Basic helix-loop-helix proteins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin kappa variable 2/OR2-1 (pseudogene)
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Synonyms gene
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Synonyms gene name
- immunoglobulin kappa variable 2/OR2-1
- immunoglobulin kappa variable 2/OR2-1 pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-18
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Entrez gene record
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Pubmed identfication
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Classification
- Immunoglobulin kappa (IGK) orphons
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namePOU class 2 homeobox 3
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Synonyms gene name
- POU domain class 2, transcription factor 3
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-11-28
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Entrez gene record
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Pubmed identfication
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Classification
- POU class homeoboxes and pseudogenes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy diversity 1/OR15-1A (non-functional)
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Synonyms gene name
- immunoglobulin heavy diversity 1/OR15-1A
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-17
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Entrez gene record
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Classification
- Immunoglobulin heavy (IGH) orphons
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VEGA ID