Granulocyte Macrophage Colony Stimulating Factor Receptor, alpha, Recombinant Human (GM-CSF Ralpha, CD116)

  • Catalog number
    MBS651027
  • Price
    Please ask
  • Size
    5x0.05 mg
  • Products_type
    Active Protein
  • Products_short_name
    [Granulocyte Macrophage Colony Stimulating Factor Receptor, alpha Human]
  • Products_name_syn
    [Granulocyte Macrophage Colony Stimulating Factor Receptor, alpha, Recombinant Human (GM-CSF R, CD116)]
  • Other_names
    [granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform g; Granulocyte-macrophage colony-stimulating factor receptor subunit alpha; granulocyte-macrophage colony-stimulating factor receptor subunit alpha; GMR-alpha; GMCSFR-alpha; CD116 antigen; OTTHUMP00000014504; OTTHUMP00000014505; OTTHUMP00000014506; OTTHUMP00000014507; OTTHUMP00000014508; OTTHUMP00000014917; OTTHUMP00000014918; OTTHUMP00000014919; OTTHUMP00000014920; GM-CSF receptor alpha subunit; colony stimulating factor 2 receptor alpha subunit; granulocyte-macrophage colony-stimulating factor receptor alpha chain; colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage); CDw116]
  • Other_gene_names
    [CSF2RA; CSF2RA; GMR; CD116; CSF2R; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; MGC3848; MGC4838; GM-CSF-R-alpha; CSF2R; CSF2RY]
  • Reactivity
    Human
  • Purity
    Purified95% by SDS­PAGE under reducing conditions and visualized by silver stain. Endotoxin: 0.01EU per 1ug of the protein by the LAL method.
  • Form
    Supplied as a lyophilized powder. Reconstitute with 100ul sterile PBS.
  • Storage_stability
    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
  • Tested_application
    ELISA (EL/EIA)
  • Description
    The Granulocyte Macrophage Colony Stimulating Factor Receptor, alpha, Recombinant (GM-CSF Ralpha, CD116) is a α- or alpha protein sometimes glycoprotein present in blood. Colonies can be formed by stimulating factors or recombinant GM-CSF and CSFs activity expressed in Units compared to a standard. Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
  • Gene
    Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and molgramostim. Reconstitution It is recommended that sterile ddH2O containing at least 0.1% human serum albumin or bovine serum albumin be added to the vial to prepare a stock solution of not less than 1 mg/mL of the cytokine.
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
    Granulocyte   Macrophage   Colony   Stimulating   Factor   Receptor   alpha   GM-CSF   Ralpha   CD116  
  • Gene symbol
    CSF2, PPP1R3A, CSF1, CSF3, CSF2RA, IL3
  • Short name
    Granulocyte Macrophage Colony Stimulating Factor Receptor, alpha, Recombinant (GM-CSF Ralpha, CD116)
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. MyBioSource advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Species
    Human, Humans
  • Alternative name
    Granulocyte Macrophage Colony Stimulating Factor Receptor, a, Rec. H. sapiens (GM-CSF Ralpha, CD116)
  • Alternative technique
    rec
  • Tissue
    granulocyte
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
MeSH Data
  • Name
    Primary Cell Culture
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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