Granulocyte Colony Stimulating Factor Receptor (G-CSFR, CD114)

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Description

Colonies can be formed by stimulating factors or recombinant GM-CSF and CSFs activity expressed in Units compared to a standard. Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

Gene target

Granulocyte Colony Stimulating Factor Receptor G-CSFR CD114
Gene symbol

CSF3R, IGHV3-71, HLA-G, NCAPG, FOLR3, SNRPG, GNAO1, CSF1R, SFTA2, BCL2L14
Short name

Granulocyte Colony Stimulating Factor Receptor (G-CSFR, CD114)
Alternative name

Granulocyte Colony Stimulating Factor Receptor (G-CSFR, CD114)
Tissue

granulocyte

Identity

HGNC:5621
Gene

IGHV3-71
Long gene name

immunoglobulin heavy variable 3-71 (pseudogene)
Synonyms gene
- IGHV3-G
Synonyms gene name
- immunoglobulin heavy variable 3-71
- immunoglobulin heavy variable 3-G pseudogene (provisional)
- immunoglobulin heavy variable 3-G (provisional)
- immunoglobulin heavy variable 3-71 pseudogene
Synonyms
- IGHV3-g
GenBank acession
- AB019437
Locus

14q32.33
Discovery year

2000-04-04
Entrez gene record

28411
RefSeq identity
- NG_001019
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000151881

Identity

HGNC:24304
Gene

NCAPG
Long gene name

non-SMC condensin I complex subunit G
Synonyms gene name
- non-SMC condensin I complex, subunit G
Synonyms
- FLJ12450
- hCAP-G
- CAP-G
- YCG1
Synonyms name
- chromosome condensation protein G
GenBank acession
- AF331796
Locus

4p15.31
Discovery year

2006-09-04
Entrez gene record

64151
Pubmed identfication
- 10910072
- 11136719
RefSeq identity
- NM_022346
Classification
- Armadillo like helical domain containing
- Condensin I subunits
VEGA ID

OTTHUMG00000128539

Identity

HGNC:4389
Gene

GNAO1
Long gene name

G protein subunit alpha o1
Synonyms gene name
- guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Synonyms
- G-ALPHA-o
Locus

16q13
Discovery year

1988-04-24
Entrez gene record

2775
Pubmed identfication
- 1899283
- 11395521
RefSeq identity
- NM_020988
Classification
- G protein subunits alpha, group i
- MicroRNA protein coding host genes
VEGA ID

OTTHUMG00000133241

Identity

HGNC:2433
Gene

CSF1R
Long gene name

colony stimulating factor 1 receptor
Synonyms gene
- FMS
Synonyms gene name
- McDonough feline sarcoma viral (v-fms) oncogene homolog
Synonyms
- C-FMS
- CSFR
- CD115
GenBank acession
- U63963
Locus

5q32
Discovery year

2001-06-22
Entrez gene record

1436
Pubmed identfication
- 1611909
RefSeq identity
- NM_005211
Classification
- Immunoglobulin like domain containing
- Receptor tyrosine kinases
- CD molecules
VEGA ID

OTTHUMG00000130050

Name

Colony-Forming Units Assay
Concept

Scope note: A cytologic technique for measuring the functional capacity of stem cells by assaying their activity.
Tree numbers
- E01.370.225.500.383
- E05.200.500.383
- E05.242.383
Qualifiers

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