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Products_type
Antibody
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Products_short_name
[FOXP3]
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Products_name_syn
[JM2; AIID; DIETER; IPEX; MGC141961; MGC141963; PIDX; XPID; FOXP3delta7; forkhead box protein P3; immune dysregulation; polyendocrinopathy; enteropathy; X-linked; immunodeficiency; polyendocrinopathy; enteropathy; X-linked; scurfin]
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Other_names
[forkhead box protein P3 isoform b; Forkhead box protein P3; forkhead box protein P3; scurfin; FOXP3delta7; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; forkhead box P3; Scurfin]
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Products_gene_name
[FOXP3]
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Other_gene_names
[FOXP3; FOXP3; JM2; AIID; IPEX; PIDX; XPID; DIETER; IPEX]
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Clonality
Monoclonal
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Clone
[3G3]
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Reactivity
Human, Monkey, Mouse.
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Specificity
Recognizes a protein of 47-55kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion (amino acids 2-136) of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.
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Form
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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Storage_stability
Store at 2 to 8 degree C. Antibody is stable for 24 months.
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Tested_application
ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistology (IH)
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Gene
Forkhead Box Protein P3 scurfin FOXP3, is a protein involved in immune system responses. A member of the FOX protein family, FOXP3 appears to function as a master regulator of the regulatory pathway in the development and function of regulatory T cells. Foxp3 or forkhead box P3 or skurfin or scurfin or skurfina is also known as IPEX, AIID, PIDX, XPID and DIETER.
