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Products_type
Antibody
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Products_short_name
[FKHR/FKHRL1]
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Products_name_syn
[Anti -FKHR/FKHRL1, phosphorylated (Thr24 Thr32) (Forkhead Family Transcription Factor)]
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Other_names
[forkhead box protein O3; Forkhead box protein O3; forkhead box protein O3; forkhead box O3A; forkhead in rhabdomyosarcoma-like 1; forkhead homolog (rhabdomyosarcoma) like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; forkhead box O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1]
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Other_gene_names
[FOXO3; FOXO3; FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2; FKHRL1; FOXO3A]
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Clonality
Polyclonal
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Reactivity
Human, Monkey, Mouse, Rat
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Specificity
Recognizes endogenous levels of human Fox01 when phosphorylated at Thr24 and Fox03a when phosphorylated at Thr32. Reacts with phosphorylated Fox04 (AFX) at Thr28 but not with Fox01 family members phosphorylated at other sites. Species Crossreactivity: mouse, rat, monkey
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Purity
Affinity Purified Purified by Protein A and peptide affinity chromatography.
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Form
Supplied as liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. No preservative added.
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Storage_stability
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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Tested_application
ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)
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Description
Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. The activation of transcription factor subunits is the first step of gene expression, in which a particular segment of DNA is copied into RNA (mRNA) by the enzyme RNA polymerases. Transcription factors, unites and elongations can be RNA and DNA nucleic acids, base pairs of nucleotides . Converting from DNA to RNA is made by enzymatic reactions. During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, anti-parallel RNA strand called a primary transcript. Transcriptions are key functions in signal transduction pathways. Signaling ligand binding transcription factors play an important role in transduction cascades.
