Desmoglein-3 (Squamous Cell Marker)

• Catalog number
  MBS439919
• Price
  Please ask
• Size
  0.1 mg (Without BSA & Azide at 1mg/mL)

• Products_type
  Antibody
• Products_short_name
  [Desmoglein-3]
• Products_name_syn
  [130kDa pemphigus vulgaris antigen (PVA); Balding (Bal); Cadherin family member 6 (CDHF6); Desmoglein-3 (DSG3)]
• Other_names
  [desmoglein-3 preproprotein; Desmoglein-3; desmoglein-3; desmoglein 3; 130 kDa pemphigus vulgaris antigen; PVA; Cadherin family member 6]
• Products_gene_name
  [DSG3]
• Other_gene_names
  [DSG3; DSG3; PVA; CDHF6; CDHF6; PVA]
• Clonality
  Monoclonal
• Clone
  [DSG3/1535]
• Reactivity
  Human. Others not known.
• Specificity
  Recognizes a protein of 130kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (>80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.
• Form
  200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Storage_stability
  Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Tested_application
  Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin
• Description
  For cells, cell lines and tissues in culture till half confluency.

• Gene target
  Desmoglein-3   Squamous  
• Short name
  Desmoglein-3 (Squamous )
• Technique
  Component cell markers and DNA bp. markers are genetic markers er genes or DNA sequences with a known location on a chromosome that can be used to identify individuals or species. Protein markers in kDA.
• Host
  Mouse
• Isotype
  IgG1, kappa
• Alternative name
  Desmoglein-3 (Squamous cellular detection labelled)
• Tissue
  cell

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