Desmoglein-1 (DSG1)

• Catalog number
  MBS439912
• Price
  Please ask
• Size
  0.1 mg (With BSA & Azide at 0.2mg/mL)

• Products_type
  Antibody
• Products_short_name
  [Desmoglein-1 (DSG1)]
• Products_name_syn
  [Cadherin family member 4; CDHF4; Desmoglein-1; Desmosomal glycoprotein 1; DG1; DSG1; EPKHE; EPKHIA; Pemphigus foliaceus antigen; PPKS1; SPPK1]
• Other_names
  [desmoglein-1 preproprotein; Desmoglein-1; desmoglein-1; desmoglein 1; Cadherin family member 4; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen]
• Products_gene_name
  [DSG1]
• Other_gene_names
  [DSG1; DSG1; DG1; DSG; CDHF4; EPKHE; PPKS1; SPPK1; EPKHIA; CDHF4; DG1; DGI]
• Clonality
  Monoclonal
• Clone
  [18D4]
• Reactivity
  Human. Others not known.
• Specificity
  Recognizes a protein of ~150kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.
• Form
  200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Storage_stability
  Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Tested_application
  Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)

• Gene target
  Desmoglein-1   DSG1  
• Gene symbol
  DSG1-AS1, DSG1
• Short name
  Desmoglein-1 (DSG1)
• Host
  Mouse
• Isotype
  IgG1, kappa
• Alternative name
  Desmoglein-1 (desmoglein 1)
• Alternative to gene target
  desmoglein 1, CDHF4 and DG1 and DSG and EPKHE and EPKHIA and PPKS1 and SPPK1, DSG1 and IDBG-2020 and ENSG00000134760 and 1828, gamma-catenin binding, Cell surfaces, DSG1 and IDBG-643764 and ENSBTAG00000013831 and 281131

Gene info

• Identity
  HGNC:51115
• Gene
  DSG1-AS1
• Long gene name
  DSG1 antisense RNA 1
• Locus
  18q12.1
• Discovery year
  2014-07-30
• Entrez gene record
  101927718
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000179625

Gene info

• Identity
  HGNC:3048
• Gene
  DSG1
• Long gene name
  desmoglein 1
• Synonyms gene
  • DSG
• Synonyms
  • CDHF4
• GenBank acession
  • X56654
• Locus
  18q12.1
• Discovery year
  1991-03-04
• Entrez gene record
  1828
• Pubmed identfication
  • 1889810
• RefSeq identity
  • NM_001942
• Classification
  • Desmosomal cadherins
• VEGA ID
  OTTHUMG00000131983

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