Cyclin B1

• Catalog number
  MBS438370
• Price
  Please ask
• Size
  0.1 mg (With BSA & Azide at 0.2mg/mL)

• Products_type
  Antibody
• Products_short_name
  [Cyclin B1]
• Products_name_syn
  [CCNB; CCNB1; CCNB1_HUMAN; G2 Mitotic Specific Cyclin B1]
• Other_names
  [G2/mitotic-specific cyclin-B1; G2/mitotic-specific cyclin-B1; G2/mitotic-specific cyclin-B1; G2/mitotic-specific cyclin B1; cyclin B1]
• Products_gene_name
  [CCNB1]
• Other_gene_names
  [CCNB1; CCNB1; CCNB; CCNB]
• Clonality
  Monoclonal
• Clone
  [V92.1]
• Reactivity
  Human, Mouse, Hamster.
• Specificity
  It recognizes a protein of 55-62kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition.
• Form
  200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Storage_stability
  Store at 2 to 8 degree C. Antibody is stable for 24 months.
• Tested_application
  ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB), Immunohistology (IH)

• Gene target
  Cyclin  
• Gene symbol
  CCNB1, CCNB1IP1P3, CCNB1IP1P1
• Short name
  Cyclin B1
• Host
  Mouse
• Isotype
  IgG1, kappa
• Alternative name
  Cyclin B1

Gene info

• Identity
  HGNC:1579
• Gene
  CCNB1
• Long gene name
  cyclin B1
• Synonyms gene
  • CCNB
• Synonyms name
  • G2/mitotic-specific cyclin B1
• GenBank acession
  • U22364
• Locus
  5q13.2
• Discovery year
  1991-12-10
• Entrez gene record
  891
• Pubmed identfication
  • 1386342
• RefSeq identity
  • NM_031966
• Classification
  • Cyclins
• VEGA ID
  OTTHUMG00000097817

Gene info

• Identity
  HGNC:37695
• Gene
  CCNB1IP1P3
• Long gene name
  cyclin B1 interacting protein 1 pseudogene 3
• Locus
  Xq21.33
• Discovery year
  2010-01-14
• Entrez gene record
  100128456
• RefSeq identity
  • NG_016614
• VEGA ID
  OTTHUMG00000021978

Gene info

• Identity
  HGNC:37693
• Gene
  CCNB1IP1P1
• Long gene name
  cyclin B1 interacting protein 1 pseudogene 1
• Locus
  1p34.1
• Discovery year
  2010-01-14
• Entrez gene record
  728887
• VEGA ID
  OTTHUMG00000008582

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