CD91, 515kD (LRP, alpha2MR, Low Density Lipoprotein Receptor-related Protein)

• Catalog number
  MBS605784
• Price
  Please ask
• Size
  5x0.05 mg

• Products_type
  Antibody
• Products_short_name
  [CD91, 515kD]
• Products_name_syn
  [Anti -CD91, 515kD (LRP, alpha2MR, Low Density Lipoprotein Receptor-related Protein)]
• Other_names
  [C4b-binding protein; C4b-binding protein; C4b-binding protein; complement component 4 binding protein]
• Other_gene_names
  [C4bp; C4bpa; C4bpa; AI195242; C4bp; C4bp]
• Clonality
  Monoclonal
• Clone
  [5F142]
• Reactivity
  Human
• Specificity
  Specifically recognizes the 515kD a-chain of human LRP/a2MR which is expressed in a restricted spectrum of cell types. A strong immunohistochemical reaction is seen in hepatocytes, tissue macrophages, subsets of neurons and astrocytes in the central nervous system, fibroblasts, smooth muscle cells, and monocyte-derived foam cells in atherosclerotic lesions in the arterial wall. Can also be used for the characterization of a subset of myelomonocytic subtypes of chronic and acute leukemia (CD 91).
• Purity
  Affinity Purified Purified by Protein A affinity chromatography.
• Form
  Supplied as a lyophilized powder from PBS, pH 7.4, 0.5% BSA. Reconstitute with 1ml sterile 40-50% glycerol, ddH2O.
• Storage_stability
  Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol, ddH2O and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
• Tested_application
  Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunofluorescence (IF)
• Description
  High and low density proteins are supplied by MyBioSource in volumes of 1. Other densities are possible. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

• Gene target
  CD91   515kD   LRP   alpha2MR   Lipoprotein   Receptor-related   Protein  
• Gene symbol
  LRP1, MVP, LRP3, RPSA, LRP4, LRP8, LRP1B, PSMG1, PTPRA
• Short name
  CD91, 515kD (LRP, alpha2MR, Lipoprotein Receptor- Protein)
• Host
  Mouse
• Isotype
  IgG1
• Alternative name
  CD91, 515kD (LRP, alpha2MR, Low Density Lipoprotein Receptor-related Protein)

Gene info

• Identity
  HGNC:6692
• Gene
  LRP1
• Long gene name
  LDL receptor related protein 1
• Synonyms gene
  • APR
  • A2MR
• Synonyms gene name
  • alpha-2-macroglobulin receptor
  • low density lipoprotein receptor-related protein 1
• Synonyms
  • LRP
  • CD91
  • LRP1A
  • APOER
  • IGFBP3R1
  • IGFBP-3R
• Synonyms name
  • transforming growth factor-β receptor type V
• GenBank acession
  • X13916
• Locus
  12q13.3
• Discovery year
  1991-08-21
• Entrez gene record
  4035
• Pubmed identfication
  • 2548950
• RefSeq identity
  • NM_002332
• Classification
  • Low density lipoprotein receptors
  • CD molecules
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000044412

Gene info

• Identity
  HGNC:7531
• Gene
  MVP
• Long gene name
  major vault protein
• Synonyms
  • LRP
  • VAULT1
• Synonyms name
  • lung resistance-related protein
• GenBank acession
  • X79882
• Locus
  16p11.2
• Discovery year
  2000-07-31
• Entrez gene record
  9961
• Pubmed identfication
  • 7585126
• RefSeq identity
  • NM_005115
• VEGA ID
  OTTHUMG00000048227

Gene info

• Identity
  HGNC:6695
• Gene
  LRP3
• Long gene name
  LDL receptor related protein 3
• Synonyms gene name
  • low density lipoprotein receptor-related protein 3
• Synonyms
  • LRP-3
  • hLRp105
• GenBank acession
  • AB009462
• Locus
  19q13.11
• Discovery year
  1998-03-02
• Entrez gene record
  4037
• Pubmed identfication
  • 9693042
  • 7959795
• Classification
  • Low density lipoprotein receptors
• VEGA ID
  OTTHUMG00000180343

Gene info

• Identity
  HGNC:6502
• Gene
  RPSA
• Long gene name
  ribosomal protein SA
• Synonyms gene
  • LAMR1
• Synonyms gene name
  • laminin receptor 1 (67kD, ribosomal protein SA)
• Synonyms
  • LRP
  • 37LRP
  • p40
  • SA
• GenBank acession
  • S37431
• Locus
  3p22.1
• Discovery year
  1992-06-03
• Entrez gene record
  3921
• Pubmed identfication
  • 1534510
  • 8760291
• RefSeq identity
  • NM_002295
• Classification
  • Small nucleolar RNA protein coding host genes
  • S ribosomal proteins
• VEGA ID
  OTTHUMG00000131296
• Locus Specific Databases
  • LRG_735

Gene info

• Identity
  HGNC:6696
• Gene
  LRP4
• Long gene name
  LDL receptor related protein 4
• Synonyms gene name
  • low density lipoprotein receptor-related protein 4
• Synonyms
  • MEGF7
  • CLSS
  • LRP-4
  • SOST2
• GenBank acession
  • AB011540
• Locus
  11p11.2
• Discovery year
  1998-03-25
• Entrez gene record
  4038
• Pubmed identfication
  • 9693030
• RefSeq identity
  • NM_002334
• Classification
  • Low density lipoprotein receptors
• VEGA ID
  OTTHUMG00000166700

Gene info

• Identity
  HGNC:6700
• Gene
  LRP8
• Long gene name
  LDL receptor related protein 8
• Synonyms gene name
  • low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
• Synonyms
  • APOER2
  • MCI1
  • LRP-8
  • HSZ75190
• GenBank acession
  • D50678
• Locus
  1p32.3
• Discovery year
  1998-08-13
• Entrez gene record
  7804
• Pubmed identfication
  • 8626535
  • 9079678
• RefSeq identity
  • NM_004631
• Classification
  • Low density lipoprotein receptors
• VEGA ID
  OTTHUMG00000008924

Gene info

• Identity
  HGNC:6693
• Gene
  LRP1B
• Long gene name
  LDL receptor related protein 1B
• Synonyms gene name
  • low density lipoprotein receptor-related protein 1B
• Synonyms
  • LRP-DIT
  • LRPDIT
• Synonyms name
  • LRP-deleted in tumors
• GenBank acession
  • AF176832
• Locus
  2q22.1-q22.2
• Discovery year
  2000-05-02
• Entrez gene record
  53353
• Pubmed identfication
  • 10766186
• RefSeq identity
  • NM_018557
• Classification
  • Low density lipoprotein receptors
• VEGA ID
  OTTHUMG00000131799

Gene info

• Identity
  HGNC:3043
• Gene
  PSMG1
• Long gene name
  proteasome assembly chaperone 1
• Synonyms gene
  • DSCR2
• Synonyms gene name
  • Down syndrome critical region gene 2
  • proteasome (prosome, macropain) assembly chaperone 1
• Synonyms
  • c21-LRP
  • LRPC21
  • PAC1
• GenBank acession
  • AJ006291
• Locus
  21q22.2
• Discovery year
  1999-09-17
• Entrez gene record
  8624
• Pubmed identfication
  • 10872820
  • 17189198
• RefSeq identity
  • NM_003720
• VEGA ID
  OTTHUMG00000066034

Gene info

• Identity
  HGNC:9664
• Gene
  PTPRA
• Long gene name
  protein tyrosine phosphatase receptor type A
• Synonyms gene
  • PTPRL2
  • PTPA
• Synonyms
  • LRP
  • HLPR
  • HPTPA
  • RPTPA
• Locus
  20p13
• Discovery year
  1990-10-02
• Pubmed identfication
  • 2172030
  • 2169617
• Classification
  • Protein tyrosine phosphatases receptor type
• VEGA ID
  OTTHUMG00000031718

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