CD8a

• Catalog number
  MBS438436
• Price
  Please ask
• Size
  0.1 mg (Without BSA & Azide at 1mg/mL)

• Products_type
  Antibody
• Products_short_name
  [CD8a]
• Products_name_syn
  [CD8 antigen; alpha polypeptide (p32); T8/Leu-2 T-lymphocyte differentiation antigen; Ly3; LYT3; MAL; T-cell surface glycoprotein CD8 alpha chain]
• Other_names
  [T-cell surface glycoprotein CD8 alpha chain isoform 1; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 alpha chain; T8 T-cell antigen; T cell co-receptor; OKT8 T-cell antigen; T-cell antigen Leu2; Leu2 T-lymphocyte antigen; CD8 antigen, alpha polypeptide (p32); T-lymphocyte differentiation antigen T8/Leu-2; CD8a molecule; T-lymphocyte differentiation antigen T8/Leu-2; CD_antigen: CD8a]
• Products_gene_name
  [CD8A]
• Other_gene_names
  [CD8A; CD8A; CD8; MAL; p32; Leu2; MAL]
• Clonality
  Polyclonal
• Reactivity
  Human.
• Specificity
  CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cell express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.
• Form
  200ï­g/ml of antibody purified from rabbit anti-serum by Protein A chromatography. Supplied in 10mM PBS, pH 7.4 with 0.05% BSA and 0.05% sodium azide. Contact us if you require this antibody in a different format.
• Storage_stability
  Store at 2 to 8 degree C. Antibody is stable for 24 months.
• Tested_application
  ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), Immunohistology (IH)

• Gene target
  CD8a  
• Gene symbol
  CD8A
• Short name
  CD8a
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  CD8a molecule
• Alternative to gene target
  CD8a molecule, CD8 and Leu2 and MAL and p32, CD8A and IDBG-59987 and ENSG00000153563 and 925, protein homodimerization activity, Extracellular, Cd8a and IDBG-155582 and ENSMUSG00000053977 and 12525, CD8A and IDBG-634911 and ENSBTAG00000021141 and 281060

Gene info

• Identity
  HGNC:1706
• Gene
  CD8A
• Long gene name
  CD8a molecule
• Synonyms gene
  • CD8
• Synonyms gene name
  • CD8 antigen, alpha polypeptide (p32)
  • T-cell surface glycoprotein CD8 alpha chain
• Locus
  2p11.2
• Discovery year
  1986-01-01
• Entrez gene record
  925
• Pubmed identfication
  • 1541829
• RefSeq identity
  • NM_001768
• Classification
  • V-set domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000130265
• Locus Specific Databases
  • CD8Abase: Mutation registry for CD8 deficiency
  • LRG_44

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