CD71/ Transferrin Receptor
-
Products_type
Antibody
-
Products_short_name
[CD71]
-
Products_name_syn
[Mtvr-1; p90; TFR1; TFRC transferrin receptor (p90 CD71); TRFR]
-
Other_names
[transferrin receptor protein 1; Transferrin receptor protein 1; transferrin receptor protein 1; transferrin receptor (p90, CD71); transferrin receptor; T9; p90; CD_antigen: CD71Cleaved into the following chain:Transferrin receptor protein 1, serum form; sTfR]
-
Products_gene_name
[TFRC]
-
Other_gene_names
[TFRC; TFRC; T9; TR; TFR; p90; CD71; TFR1; TRFR; TR; TfR; TfR1; Trfr; sTfR]
-
Clonality
Monoclonal
-
Clone
[DF1513]
-
Reactivity
Human.
-
Specificity
It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa (Workshop IV). This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.
-
Form
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
-
Storage_stability
Store at 2 to 8 degree C. Antibody is stable for 24 months.
-
Tested_application
ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistology (IH)
-
Description
The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
Gene info
-
Identity
-
Gene
-
Long gene name
transferrin receptor
-
Synonyms gene name
- transferrin receptor (p90, CD71)
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year
2001-06-22
-
Entrez gene record
-
Classification
- M28 metallopeptidases
- CD molecules
-
VEGA ID
Similar products