CD33
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Catalog numberMBS438512
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PricePlease ask
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Size5x0.5 mL
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Products_typeAntibody
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Products_short_name[CD33]
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Products_name_syn[gp67; My9; Myeloid cell surface antigen CD33; p67; Sialic acid-binding Ig-like lectin 3 (SIGLEC3)]
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Other_names[myeloid cell surface antigen CD33 isoform 2; Myeloid cell surface antigen CD33; myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3; CD33 molecule; Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD_antigen: CD33]
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Products_gene_name[CD33]
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Other_gene_names[CD33; CD33; p67; SIGLEC3; SIGLEC-3; SIGLEC3; Siglec-3]
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ClonalityMonoclonal
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Clone[WM53]
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ReactivityHuman.
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SpecificityRecognizes a 67kDa glycoprotein, which is identified as CD33 (HLDA IV; WS Code M-505). CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.
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PurityPurified Ab conjugated to PE
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FormAntibody purified from Bioreactor Concentrate by Protein A/G and conjugated to various reporter molecules. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide. Contact us if you require this Ab in a different format.
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Storage_stabilityStore at 2 to 8 degree C. Antibody is stable for 24 months.
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Tested_applicationFlow Cytometry (FC/FACS)
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Gene target
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Gene symbolCD33
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Short nameCD33
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HostMouse
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IsotypeIgG1, kappa
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Alternative nameCD33 molecule
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Alternative to gene targetCD33 molecule, p67 and SIGLEC-3 and SIGLEC3, CD33 and IDBG-65737 and ENSG00000105383 and 945, protein binding, Cell surfaces
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Gene info
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Identity
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Gene
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Long gene nameCD33 molecule
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Synonyms gene name
- CD33 antigen (gp67)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- CD molecules
- Sialic acid binding Ig like lectins
- V-set domain containing
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VEGA ID