CD32 (Fc Gamma RIIa) Mouse Monoclonal Antibody
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Catalog numberMBS439416
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Price:
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Size5x0.1 mg (With BSA & Azide at 0.2mg/mL)
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Products_typeAntibody
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Products_short_name[CD32]
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Products_name_syn[CD32A; Fc fragment of IgG low affinity IIa receptor; Fc gamma RIIa; Fc-gamma RII-a; Fc-gamma-RIIa; FCGR2A; FcgRII; Fcr-2; FcRII-a; IGFR2; IgG Fc receptor II-a; Low affinity immunoglobulin gamma Fc region receptor II-a; Ly-17; Ly-m20; LyM-1; Lymphocyte antigen 17]
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Other_names[low affinity immunoglobulin gamma Fc region receptor II-a isoform 1; Low affinity immunoglobulin gamma Fc region receptor II-a; low affinity immunoglobulin gamma Fc region receptor II-a; Fc fragment of IgG receptor IIa; CDw32; Fc-gamma RII-a; Fc-gamma-RIIa; FcRII-a; CD_antigen: CD32]
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Products_gene_name[FCGR2A]
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Other_gene_names[FCGR2A; FCGR2A; CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1; CD32; FCG2; FCGR2A1; IGFR2; IgG Fc receptor II-a; Fc-gamma-RIIa; FcRII-a]
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ClonalityMonoclonal
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Clone[8.7]
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ReactivityHuman. Others not tested
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SpecificityThis MAb reacts with a CD32 (FcgRII) epitope distinct from that defined by MAb 8.26 and the epitope overlaps with that of MAb 7.30 (cluster 4). It displays a stronger reaction with Daudi than with U937 cells. The epitope is located in domain 2 of FcgRIIa. Its Fab'2 fragments block immune complex binding. CD32 (FcgRII) is a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes.
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Form200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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Storage_stabilityAntibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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Tested_applicationFunctional Studies, Flow Cytometry (FC/FACS), Immunofluorescence (IF)
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PropertiesIf you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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AboutMonoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
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TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin nameMus musculus
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French translationanticorps
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Gene target
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Gene symbolFCGR2B, FCGR2A
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Short nameCD32 (Fc Gamma RIIa) Mouse Monoclonal Antibody
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TechniqueMouse monoclonal, Antibody, Mouse, FC, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
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HostMouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
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IsotypeIgG1, kappa
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SpeciesMouse, Mouses
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Alternative nameCD32 (fragment c g RIIa) Mouse monoclonal (antibody to-)
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Alternative techniqueantibodies, murine
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Gene info
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Identity
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Gene
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Long gene nameFc gamma receptor IIb
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Synonyms gene
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Synonyms gene name
- Fc fragment of IgG, low affinity IIb, receptor for (CD32)
- Fc fragment of IgG, low affinity IIb, receptor (CD32)
- Fc fragment of IgG receptor IIb
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Synonyms
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GenBank acession
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Locus
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Discovery year1991-08-21
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- CD molecules
- Immunoglobulin like domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameFc gamma receptor IIa
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Synonyms gene
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Synonyms gene name
- Fc fragment of IgG, low affinity IIa, receptor for (CD32)
- Fc fragment of IgG, low affinity IIa, receptor (CD32)
- Fc fragment of IgG receptor IIa
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1988-11-30
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Immunoglobulin like domain containing
- CD molecules
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data