CD28

Products_type

Antibody
Products_short_name

[CD28]
Products_name_syn

[T-cell-specific surface glycoprotein CD28; Tp44]
Other_names

[T-cell-specific surface glycoprotein CD28 isoform 2; T-cell-specific surface glycoprotein CD28; T-cell-specific surface glycoprotein CD28; CD28 antigen; CD28 molecule; TP44; CD_antigen: CD28]
Products_gene_name

[CD28]
Other_gene_names

[CD28; CD28; Tp44]
Clonality

Monoclonal
Clone

[C28/75]
Reactivity

Human.
Specificity

Recognizes a glycoprotein of 44-88kDa, which is identified as CD28. It is the critical T-cell co-stimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its co-stimulation role, CD28 functions in preventing T-cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.
Form

supplied as 200ug/ml of AB purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide.
Storage_stability

Antibody with azide store at 2 to 8 degree C. Antibody is stable for 24 months.
Tested_application

ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Functional Studies, Immunoprecipitation (IP), Immunohistology (IH)

Gene target

CD28
Gene symbol

CD28
Short name

CD28
Host

Mouse
Isotype

IgG1, kappa
Alternative name

CD28 molecule
Alternative to gene target

CD28 molecule, Tp44, CD28 and IDBG-79183 and ENSG00000178562 and 940, identical protein binding, Cell surfaces, Cd28 and IDBG-159608 and ENSMUSG00000026012 and 12487, CD28 and IDBG-643371 and ENSBTAG00000007445 and 281050

Identity

HGNC:1653
Gene

CD28
Long gene name

CD28 molecule
Synonyms gene name
- CD28 antigen (Tp44)
Synonyms name
- T-cell-specific surface glycoprotein
GenBank acession
- J02988
Locus

2q33.2
Discovery year

1988-05-11
Entrez gene record

940
Pubmed identfication
- 1355979
RefSeq identity
- NM_006139
Classification
- CD molecules
- Ig-like cell adhesion molecule family
- V-set domain containing
VEGA ID

OTTHUMG00000132878