CD146, Recombinant, Human (Mucin 18, MUC18 Glycoprotein, Melanoma Associated Antigen A32, S-endo 1 Endothelial Associated Antigen, Melanoma Adhesion Molecule Mel-CM)

• Catalog number
  MBS637891
• Price
  Please ask
• Size
  0.002 mg

• Products_type
  Recombinant Protein
• Products_short_name
  [CD146]
• Other_names
  [cell surface glycoprotein MUC18; Cell surface glycoprotein MUC18; cell surface glycoprotein MUC18; Gicerin; melanoma adhesion molecule; cell surface glycoprotein P1H12; melanoma-associated antigen A32; melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; melanoma cell adhesion molecule; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen]
• Other_gene_names
  [MCAM; MCAM; CD146; MUC18; MUC18]
• Purity
  PurifiedPurified by proprietary chromatographic techniques. On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 47kD
• Form
  Supplied as a liquid in 50mM Tris-acetate, pH 7.5, 1mM EDTA, 20% glycerol.
• Storage_stability
  For long-term storage, aliquot and stoe at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
• Description
  cell adhesion molecules play a role in cell growth and activation and are often identified by WB or ELISA as in the CD146, Recombinant, (Mucin 18, MUC18 Glycoprotein, Melanoma Associated Antigen A32, S-endo 1 Endothelial Associated Antigen, Melanoma Adhesion Molecule Mel-CM). Antigens are peptides or recombinant or native dependent on the production method. Whole adhesion and interacting molecules are  present in lysates used as reference for ELISA quantification of these molecules and their subunits.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CD146   Mucin   MUC18   Glycoprotein   Melanoma   Associated   A32   S-endo   Endothelial   Associated   Melanoma   Adhesion   Molecule   Mel-CM  
• Gene symbol
  MCAM, RASA1
• Short name
  CD146, Recombinant, (Mucin 18, MUC18 Glycoprotein, Melanoma Associated Antigen A32, S-endo 1 Endothelial Associated Antigen, Melanoma Adhesion Molecule Mel-CM)
• Technique
  Recombinant, antigen, antigenes, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. MyBioSource advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Host
  E Coli
• Species
  Human, Humans
• Alternative name
  CD146, Rec., H. sapiens (Mucin 18, MUC18 Glycoprotein, Melanoma Associated protein A32, S-endo 1 Endothelial Associated protein, Melanoma Adhesion Molecule Mel-CM)
• Alternative technique
  rec, antigenes

Gene info

• Identity
  HGNC:6934
• Gene
  MCAM
• Long gene name
  melanoma cell adhesion molecule
• Synonyms
  • MUC18
  • CD146
  • MelCAM
  • METCAM
  • HEMCAM
• Synonyms name
  • Gicerin
• GenBank acession
  • X68264
• Locus
  11q23.3
• Discovery year
  1995-12-18
• Entrez gene record
  4162
• Pubmed identfication
  • 2602381
  • 10702685
  • 19229070
• Classification
  • Ig-like cell adhesion molecule family
  • C2-set domain containing
  • V-set domain containing
  • MicroRNA protein coding host genes
  • CD molecules
• VEGA ID
  OTTHUMG00000166197

Gene info

• Identity
  HGNC:9871
• Gene
  RASA1
• Long gene name
  RAS p21 protein activator 1
• Synonyms gene
  • RASA
• Synonyms gene name
  • RAS p21 protein activator (GTPase activating protein) 1
• Synonyms
  • GAP
  • CM-AVM
  • p120GAP
  • p120RASGAP
  • p120
• Synonyms name
  • capillary malformation-arteriovenous malformation
  • p120 RAS GTPase activating protein
• Locus
  5q14.3
• Discovery year
  1989-06-30
• Entrez gene record
  5921
• Pubmed identfication
  • 15917201
• RefSeq identity
  • NM_002890
• Classification
  • SH2 domain containing
  • C2 and RasGAP domain containing
  • Pleckstrin homology domain containing
• VEGA ID
  OTTHUMG00000162605
• Locus Specific Databases
  • SH2base: Database for pathogenic SH2 domain mutations

MeSH Data

• Name
  Mammary Neoplasms, Experimental
• Concept
  Scope note: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
• Tree numbers
  • C04.588.531.500
  • C04.619.590
  • E05.598.500.496.843
• Qualifiers
  diagnosis, parasitology, immunology, microbiology, diagnostic imaging, physiopathology, secondary, enzymology, etiology, mortality, epidemiology, blood, cerebrospinal fluid, chemically induced, congenital, diet therapy, drug therapy, therapy, chemistry, psychology, urine, virology, history, blood supply, classification, economics, embryology, genetics, nursing, radiotherapy, prevention & control, pathology, ultrastructure, metabolism, complications, surgery

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