Catenin, delta-1 (CTNND1) (pTyr96)
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Products_type
Antibody
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Products_short_name
[Catenin, delta-1 (CTNND1)]
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Products_name_syn
[Cadherin-associated Src substrate (CAS); Catenin (cadherin associated protein) delta 1; Catenin delta-1; CTNND1; p120 catenin; P120 CTN; p120(cas); p120(ctn); P120CAS; P120CTN]
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Other_names
[catenin delta-1 isoform 1ABC; Catenin delta-1; Cadherin-associated Src substrate; CAS; p120 catenin; p120(ctn); p120(cas)]
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Products_gene_name
[CTNND1]
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Other_gene_names
[CTNND1; KIAA0384; CAS; p120(ctn)]
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Clonality
Monoclonal
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Clone
[25a]
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Reactivity
Human, Rat. Others not known.
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Specificity
The membrane associated protein pp120 Src substrate (p120 Catenin, p120cas) was identified as a tyrosine kinase substrate that is phosphorylated in Src transformed cells or in response to growth factor stimulation. It shares structural similarity with the Drosophila Armadillo protein and the vertebrate beta-catenin and gamma-catenin proteins. Its characteristic Arm domain that is composed of 42-amino acid motif repeats evidences this similarity. In the cell, p120 Catenin is localized to the E-Cadherin/catenins cell adhesion complex. Like beta- and gamma-catenin, p120 Catenin directly associates with the cytoplasmic C-terminus of E-Cadherin via its Arm domain and may similarly interact with other Cadherins. It exists as four isoforms that range in size from 90-115kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered pp120 expression contributes to malignancy due to loss of functional cell adhesions. Multiple tyrosine residues (Y96, Y112, Y228, Y280, Y257, Y291, Y296, and Y302) in p120 Catenin are phosphorylated by Src and these phosphorylations may facilitate interaction with PTP1C/SHP-1 in response to EGF stimulation. Thus, p120 Catenin is an Arm domain protein that interacts with both cell adhesion molecules, such as cadherins and cell signaling molecules, such as PTP1C.
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Form
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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Storage_stability
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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Tested_application
Flow Cytometry (FC/FACS), Immunofluorescence (IF)
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Gene target
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Gene symbol
TMX2-CTNND1, CTNND1
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Short name
Catenin, delta-1 (CTNND1) (pTyr96)
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Host
Mouse
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Isotype
IgG1, kappa
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Alternative name
Catenin, delta-1 (catenin (cadherin-associated protein), delta 1) (pTyr96)
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Alternative to gene target
catenin (cadherin-associated protein), delta 1, CAS and CTNND and p120 and p120(CAS) and p120(CTN) and P120CAS and P120CTN, CTNND1 and IDBG-47085 and ENSG00000198561 and 1500, cell adhesion molecule binding, nuclei, Ctnnd1 and IDBG-184766 and ENSMUSG00000034101 and 12388, CTNND1 and IDBG-637886 and ENSBTAG00000002411 and 515187
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Gene info
Gene info
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Identity
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Gene
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Long gene name
catenin delta 1
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Synonyms gene
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Synonyms gene name
- catenin (cadherin-associated protein), delta 1
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Synonyms
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GenBank acession
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Locus
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Discovery year
1995-09-18
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Armadillo repeat containing
- p120 catenin family
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VEGA ID
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