Anti-Lymphotoxin alpha [3F12.2D3]
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Catalog number
MBS488356
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Price
Please ask
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Size
5x0.2 mg
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Products_type
Recombinant Antibody
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Products_short_name
[Lymphotoxin alpha]
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Products_name_syn
[chimeric 3F12; LT; LTalpha3; Tumor necrosis factor beta; Tumor necrosis factor beta; Tumor necrosis factor-beta; tumor necrosis factor-beta; TNF beta; TNF-beta; TNF beta; TNF-beta; Lymphotoxin-alpha; Lymphotoxin alpha]
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Other_names
[lymphotoxin-alpha; Lymphotoxin-alpha; lymphotoxin-alpha; lymphotoxin alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1]
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Products_gene_name
[LTalpha]
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Other_gene_names
[LTA; LTA; LT; TNFB; TNFSF1; TNLG1E; TNFB; TNFSF1; LT-alpha]
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Clonality
Monoclonal
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Clone
[3F12.2D3]
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Reactivity
Human
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Specificity
3F12 binds to human LTalpha3 and LTalphabeta (with a KD of ~0.3 nM, determined by BIACORE; ~ 37 pM, determined by ELISA) in both its soluble homotrimeric and membrane heterotrimeric forms. LTalpha belongs to the tumor necrosis factor (TNF) superfamily and is secreted as a homo-trimer (LTalpha3), or is expressed on the cell surface in complex with LTbeta. Lymphotoxin is produced by lymphocytes and in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. LTalpha3 signaling induces target cells to upregulate many chemokines and cytokines in an NFkB-dependent manner.
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Purity
Protein A Affinity Purified
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Concentration
1 mg/ml
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Storage_stability
Store at 4 degree C for up to 3 months. For longer storage, aliquot and store at -20 degree C.
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Tested_application
Neutralization, ELISA (EIA), Flow Cytometry (FC/FACS), Surface Plasmon Resonance (SPR)
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Description
The Anti-Lymphotoxin alpha [3F12 2D3] is a α- or alpha protein sometimes glycoprotein present in blood. This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Gene target
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Short name
Anti-Lymphotoxin alpha [3F12 2D3]
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Technique
anti-, anti, antibody to, antibodies
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Isotype
Mouse IgG2b, Kappa
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Alternative name
Antibody toLymphotoxin a [3F12.2D3]
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Alternative technique
antibodies
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MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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