Anti-Integrin beta-7 [FIB27]

• Catalog number
  MBS488443
• Price
  Please ask
• Size
  0.2 mg

• Products_type
  Recombinant Antibody
• Products_short_name
  [Integrin beta-7]
• Products_name_syn
  [FIB-27; FIB 27; Fib-27; Fib27; Fib 27; fib27; fib-27; fib 27; Integrin b7; integrin b-7; Gut homing receptor beta subunit; FIB27]
• Other_names
  [integrin beta-7; Integrin beta-7; integrin beta-7; integrin subunit beta 7; Gut homing receptor beta subunit]
• Products_gene_name
  [ITGB7]
• Other_gene_names
  [ITGB7; ITGB7]
• Clonality
  Monoclonal
• Clone
  [FIB27]
• Reactivity
  Human, Mouse
• Specificity
  FIB27 binds specifically to both human and mouse integrin beta-7 at epitope region Dl on which is involved in all a4b7-mediated adhesion events. Does not compete with DAKT32 for binding. FIB27 blocks LS722-induced TK1 cell aggregation (mAb LS722 is an activating anti-a4B7 antibody and induces aggregation via an a4B7-dependent pathway). Integrin beta-7 is one subunit is a heterodimer which makes up an intergin molecule. In the mouse beta-7 is selectively found on the majority of mature lymphocytes, whereas a small subpopulation of thymocytes and bone marrow cells express beta-7. Beta-7 is also expressed in variable amounts in CD4 T memory cells. Integrin molecules mediate cell-cell and cell-extracellular matrix adhesion and are involved in lymphocyte homing, leukocyte recruitment to inflammatory sites, myogenesis, hemopoiesis, and melanoma metastasis.
• Purity
  Protein A Affinity Purified
• Form
  PBS with 0.02% Proclin 300.
• Concentration
  1mg/ml
• Storage_stability
  Store at 4 degree C for up to 3 months. For longer storage, aliquot and store at -20 degree C.
• Tested_application
  Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Blocking (BL)
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.

• Gene target
  Integrin   beta-7   [FIB27]  
• Short name
  Anti-Integrin beta-7 [FIB27]
• Technique
  anti-, anti, antibody to, antibodies
• Isotype
  Rat IgG2a kappa
• Alternative name
  Antibody toIntegrin b-7 [FIB27]
• Alternative technique
  antibodies

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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