12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
MeSH code information
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Name
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Concept
Registry number:
59985-28-3
Scope note:
A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)
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Tree numbers
- D10.251.355.255.100.300.425
- D10.251.355.310.166.550.425
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Qualifiers
isolation & purification, immunology, pharmacokinetics, biosynthesis, physiology, therapeutic use, agonists, blood, cerebrospinal fluid, chemical synthesis, deficiency, chemistry, urine, radiation effects, history, analysis, classification, economics, genetics, pharmacology, standards, administration & dosage, antagonists & inhibitors, analogs & derivatives, supply & distribution, poisoning, adverse effects, toxicity, metabolism
