Interleukin (IL)-6 Receptor

Alternative_Names

Thr-Ser-Leu-Pro-Val-Gln-Asp-Ser-Ser-Ser-Val-Pro;TSLPVQDSSSVP
CAS

NA
MWt

1216.30
Formula

C51H85N13O21
Solubility

H2O
Clinical_Information

No Development Reported
Pathway

Others
Target

Others
Datasheet
SDS
Description

The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

Identity

HGNC:6019
Gene

IL6R
Long gene name

interleukin 6 receptor
Synonyms
- CD126
- IL-6R
- IL-1Ra
- IL6RA
- gp80
Synonyms name
- membrane glycoprotein 80
- interleukin 6 receptor subunit alpha
GenBank acession
- X12830
Locus

1q21.3
Discovery year

2001-06-22
Entrez gene record

3570
Pubmed identfication
- 8428753
- 12633863
RefSeq identity
- NM_000565
Classification
- CD molecules
- Interleukin receptors
- Immunoglobulin like domain containing
VEGA ID

OTTHUMG00000036073

Identity

HGNC:6021
Gene

IL6ST
Long gene name

interleukin 6 cytokine family signal transducer
Synonyms gene name
- interleukin 6 signal transducer (gp130, oncostatin M receptor)
- interleukin 6 signal transducer
Synonyms
- GP130
- CD130
- sGP130
- IL-6RB
Synonyms name
GenBank acession
- M57230
Locus

5q11.2
Discovery year

1991-08-12
Entrez gene record

3572
Pubmed identfication
- 2261637
RefSeq identity
- NM_002184
Classification
- Fibronectin type III domain containing
- CD molecules
- Interleukin receptors
VEGA ID

OTTHUMG00000097043

Identity

HGNC:6004
Gene

IL20RB
Long gene name

interleukin 20 receptor subunit beta
Synonyms gene
- FNDC6
Synonyms gene name
- fibronectin type III domain containing 6
- interleukin 20 receptor beta
- interleukin 20 receptor beta subunit
Synonyms
- DIRS1
- IL-20R2
- MGC34923
GenBank acession
- BC033292
Locus

3q22.3
Discovery year

2000-05-23
Entrez gene record

53833
Pubmed identfication
- 11163236
- 16703417
RefSeq identity
- NM_144717
Classification
- Interleukin receptors
- Fibronectin type III domain containing
VEGA ID

OTTHUMG00000159779