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Alternative name1
Anti-RABBIT ANTI RAT GABA B RECEPTOR 1 (pSer923)
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Alternative name2
RABBIT ANTI RAT GABA B RECEPTOR 1 (pSer923)
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Alternative name3
Lapin ANTI Rattus norvegicus GABA B RECEPTOR 1 (pSer923)
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Alternative name4
GABA B RECEPTOR 1
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Alternative name5
N/A
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Other names
gamma-aminobutyric acid type B receptor subunit 1; Gamma-aminobutyric acid type B receptor subunit 1; gamma-aminobutyric acid type B receptor subunit 1; gb1; GABABR1; GABA-BR1; GABA-B-R1; GABA-B receptor 1; gamma-aminobutyric acid (GABA) B receptor 1; N/A
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Gene name
N/A
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Gene name synonims
N/A
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Other gene names
Gabbr1; Gabbr1; N/A; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABABR1; Gb1
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Category
Antibodies
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Clonality
Polyclonal
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Immunoglobulin isotype
Polyclonal IgG
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Clone
Polyclonal antibody
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Host organism
Rabbit
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Species reactivity
Rat
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Specificity and cross reactivity
GABA B RECEPTOR 1 This item specifically recognises the 102kDa transmembrane gamma-aminobutyric acid B (GABAB) receptor 1 (GABR1), when phosphorylated at Ser923. _x000D__x000D_GABAB receptors are heterodimeric G-protein coupled receptors which are important mediators of slow neuronal inhibition in the mammalian central nervous system. The functional expression of GABAB receptors on plasma membranes is dependent upon the co-expression of GABR1 and GABR2 (gamma-aminobutyric acid B (GABAB) receptor 2). Phosphorylation of GABR1 at the Ser923 site may be an important factor in the regulation of GABAB receptor function. _x000D__x000D_Abnormalities in the expression or function of GABAB receptors have become a focus area in studies of temporal lobe epilepsy (TLE).
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Purification method
N/A
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Form Appearance
Purified (Purified IgG - liquid)
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Concentration
N/A
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Storage and shipping
Store at +Store productone at +4 degrees Celsius. or productone should be stored at -20 degrees Celsius. if preferred. Storage in frost-free freezers is not recommended. productone should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should productone contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of dispatch.
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Tested for
Western Blot (WB)
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Description
productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in. Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, they are inexpensive to manufacture and respectively to buy, the time needed for production is considerably shorter. Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions. To obtain more detailed information on productone, please, refer to the full product datasheet.
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Advisory
In order to retain the quality and the affinity of productone unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
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Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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About
Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
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Latin name
Rattus norvegicus
