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Alternative name1
Anti-RABBIT ANTI RAT AQUAPORIN 2 (pSer261)
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Alternative name2
RABBIT ANTI RAT AQUAPORIN 2 (pSer261)
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Alternative name3
Lapin ANTI Rattus norvegicus AQUAPORIN 2 (pSer261)
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Alternative name4
AQUAPORIN 2
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Alternative name5
N/A
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Other names
aquaporin-2; Aquaporin-2; aquaporin-2; AQP-CD; WCH-CD; aquaporin-CD; ADH water channel; collecting duct water channel protein; water channel protein for renal collecting duct; aquaporin 2 (collecting duct); ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct
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Gene name
N/A
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Gene name synonims
N/A
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Other gene names
Aqp2; Aqp2; AQP-2; aquaporin-2; AQP-2; AQP-CD
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Category
Antibodies
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Clonality
Polyclonal
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Immunoglobulin isotype
Polyclonal IgG
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Clone
Polyclonal antibody
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Host organism
Rabbit
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Species reactivity
Rat
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Specificity and cross reactivity
AQUAPORIN 2 This item specifically recognises the 29kDa integral membrane protein Aquaporin 2 (AQP2), when phosphorylated at Ser261. _x000D__x000D_AQP2 provides the plasma membranes of the renal collecting duct with a high permeability channel to enable the movement of water across an osmotic gradient, under hormonal regulation by vasopressin. In addition to the Ser256 phosphorylation site, studies have identified a novel phosphorylated Ser261 site on AQP2, which decreases in expression, in response to vasopressin. _x000D__x000D_Gene mutations in AQP2 result in hereditary nephrogenic diabetes insipidus in humans, and acquired diabetes insipidus can also occur through a decrease in the expression of the AQP2 gene, following lithium treatment. Expression of the AQP2 gene is increased during pregnancy and other conditions associated with water retention.
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Purification method
N/A
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Form Appearance
Purified (Purified IgG - liquid)
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Concentration
N/A
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Storage and shipping
Store at +Store productone at +4 degrees Celsius. or productone should be stored at -20 degrees Celsius. if preferred. Storage in frost-free freezers is not recommended. productone should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should productone contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of dispatch.
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Tested for
Western Blot (WB)
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Description
productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in. Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, they are inexpensive to manufacture and respectively to buy, the time needed for production is considerably shorter. Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions. To obtain more detailed information on productone, please, refer to the full product datasheet.
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Advisory
In order to retain the quality and the affinity of productone unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
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Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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About
Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
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Latin name
Rattus norvegicus
