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Alternative name1
Anti-RABBIT ANTI HUMAN CD49b
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Alternative name2
RABBIT ANTI HUMAN CD49b
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Alternative name3
Lapin ANTI Homo sapiens CD49b
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Alternative name4
CD49b
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Alternative name5
N/A
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Other names
integrin alpha-2; Integrin alpha-2; integrin alpha-2; collagen receptor; platelet antigen Br; platelet glycoprotein GPIa; VLA2 receptor, alpha-2 subunit; CD49 antigen-like family member B; platelet membrane glycoprotein Ia; human platelet alloantigen system 5; very late activation protein 2 receptor, alpha-2 subunit; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha
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Gene name
CD49b
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Gene name synonims
N/A
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Other gene names
ITGA2; ITGA2; BR; GPIa; CD49B; HPA-5; VLA-2; VLAA2; CD49B; GPIa
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Category
Antibodies
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Clonality
Polyclonal
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Immunoglobulin isotype
Polyclonal IgG
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Clone
Polyclonal antibody
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Host organism
Rabbit
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Species reactivity
Human
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Specificity and cross reactivity
CD49b This item detects an epitope within the extracellular domain of human CD49b, also known as integrin alpha-2 (ITGA2). CD49b is a 160kD glycoprotein that non-covalently associates with integrin beta 1 (CD29) to form the VLA-2 complex._x000D_This complex is involved in cell adhesion and cell-surface mediated signalling, and functions as a cell surface receptor for many types of collagen. Originally identified on activated human T lymphocytes, this complex was subsequently shown to be present on a wide variety of cell types including fibroblasts and platelets. _x000D__x000D_VLA-2 has been linked to cardiovascular disease, cancer development and metastasis. CD49b has been identified on a subset of regulatory T cells which produce interleukin 10 (IL-10).
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Purification method
N/A
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Form Appearance
Purified (Purified IgG - liquid)
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Concentration
IgG concentration 0.7mg/ml
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Storage and shipping
Store at +Store productone at +4 degrees Celsius. or productone should be stored at -20 degrees Celsius. if preferred. Storage in frost-free freezers is not recommended. productone should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should productone contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of dispatch.
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Tested for
Immunohistology - Paraffin (IHC)
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Description
productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in. Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, they are inexpensive to manufacture and respectively to buy, the time needed for production is considerably shorter. Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions. To obtain more detailed information on productone, please, refer to the full product datasheet.
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Advisory
In order to retain the quality and the affinity of productone unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
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Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Test
MBS Polyclonals supplies antibodies that are for research of human proteins.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
