Tumor Necrosis Factor Receptor 2, p75/p80 (TNFR 2, Tnfr2, Tnfr-2, TNF-R2, Tumor Necrosis Factor Receptor Type II, TNFRII, TNFR-II, TNF-RII, TNF-R-II, CD120b, p75, p80 TNF alpha Receptor, TNF-R75, TNFR80, TNFalpha-R2, TNF-alphaR2, Tumor Necrosis Factor bet

• Catalog number
  GEN632644
• Price
  Please ask
• Size
  1 mililiter

• Also known as
  Tumor Necrosis Factor Receptor 2, p75/p80
• Other names
  tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily member 1B; TNF-R2; TNF-RII; p75 TNF receptor; p80 TNF-alpha receptor; soluble TNFR1B variant 1; tumor necrosis factor receptor 2; tumor necrosis factor beta receptor; tumor necrosis factor receptor type II; tumor necrosis factor binding protein 2; tumor necrosis factor receptor superfamily, member 1B; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; CD_antigen: CD120b; INN: EtanerceptCleaved into the following 2 chains:Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2Alternative name(s):TBP-2; TBPII
• Category
  Antibodies
• Subcategory
  Mnoclonal antibodies
• Gene name
  TNFRSF1B; TNFRSF1B; p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II; TNFBR; TNFR2; TNF-R2; TNF-RII; TNFR-II
• Gene name synonims
  TNFRSF1B; TNFRSF1B; p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II; TNFBR; TNFR2; TNF-R2; TNF-RII; TNFR-II
• Other gene names
  TNFRSF1B; TNFRSF1B; p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II; TNFBR; TNFR2; TNF-R2; TNF-RII; TNFR-II
• Clonality
  Monoclonal
• Immunoglobulin isotype
  IgG2a
• Clone
  HM102
• Host organism
  Rat (Rattus norvegicus)
• Source organism
  Mouse (Mus musculus)
• Species reactivity
  Mouse (Mus musculus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
• Specificity and cross reactivity
  Recognizes the extra-cellular part of mouse TNF-RII and with the soluble receptor. ; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
• Purification method
  Affinity Purified
• Form Appearance
  Supplied as a liquid in PBS, 0.1% BSA.
• Concentration
  N/A
• Storage and shipping
  Store the antibody at +4 degrees Celsius for short term storage.. Aliquot to avoid repeated freezing and thawing. For optimal long term storage, the antibody should be kept at -20 degrees Celsius. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Tested applications
  ELISA (EL/EIA), Immunoprecipitation (IP), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
• Description
  The Tumor Necrosis Factor Receptor 2, p75/p80 (TNFR 2, Tnfr2, Tnfr-2, TNF-R2, Tumor Necrosis Factor Receptor II, TNFRII, TNFR-II, TNF-RII, TNF-R-II, CD120b, p75, p80 TNF alpha Receptor, TNF-R75, TNFR80, TNFalpha-R2, TNF-alphaR2, Tumor Necrosis Factor bet is a α- or alpha protein sometimes glycoprotein present in blood. Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• Gene
  Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.

• Gene target
  Tumor   Necrosis   Factor   Receptor   p75/p80   TNFR   Tnfr2   Tnfr-2   TNF-R2   Tumor   Necrosis   Factor   Receptor   TNFRII   TNFR-II   TNF-RII   TNF-R-II   CD120b   p75   p80   TNF   alpha   Receptor   TNF-R75   TNFR80   TNFalpha-R2   TNF-alphaR2   Tumor   Necrosis   Factor   bet  
• Gene symbol
  TNFRSF1B, TNF, TNFRSF1A, LTBR, PCAT7, CD82, CLDN3, TNFRSF10B, SPINK2, CRABP2
• Short name
  Tumor Necrosis Factor Receptor 2, p75/p80 (TNFR 2, Tnfr2, Tnfr-2, TNF-R2, Tumor Necrosis Factor Receptor II, TNFRII, TNFR-II, TNF-RII, TNF-R-II, CD120b, p75, p80 TNF alpha Receptor, TNF-R75, TNFR80, TNFalpha-R2, TNF-alphaR2, Tumor Necrosis Factor bet
• Alternative name
  Anti-Tumor Necrosis Factor Receptor 2, p75/p80 (TNFR 2, Tnfr2, Tnfr-2, TNF-R2, Tumor Necrosis Factor Receptor Type II, TNFRII, TNFR-II, TNF-RII, TNF-R-II, CD120b, p75, p80 TNF alpha Receptor, TNF-R75, TNFR80, TNFalpha-R2, TNF-alphaR2, Tumor Necrosis Factor bet
• Alternative to gene target
  tumor necrosis factor, DIF and TNF-alpha and TNFA and TNFSF2, TNF and IDBG-300259 and ENSG00000232810 and 7124, transcription regulatory region DNA binding, Extracellular, Tnf and IDBG-177358 and ENSMUSG00000024401 and 21926, TNF and IDBG-634161 and ENSBTAG00000025471 and 280943
• Tissue
  tumor

Gene info

• Identity
  HGNC:11917
• Gene
  TNFRSF1B
• Long gene name
  TNF receptor superfamily member 1B
• Synonyms gene
  • TNFR2
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 1B
• Synonyms
  • TNFBR
  • TNFR80
  • TNF-R75
  • TNF-R-II
  • p75
  • CD120b
• GenBank acession
  • M32315
• Locus
  1p36.22
• Discovery year
  1991-01-15
• Entrez gene record
  7133
• Pubmed identfication
  • 2158863
  • 8702885
• RefSeq identity
  • NM_001066
• Classification
  • CD molecules
  • MicroRNA protein coding host genes
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000001829

Gene info

• Identity
  HGNC:11892
• Gene
  TNF
• Long gene name
  tumor necrosis factor
• Synonyms gene
  • TNFA
• Synonyms gene name
  • tumor necrosis factor (TNF superfamily, member 2)
• Synonyms
  • TNFSF2
  • DIF
  • TNF-alpha
• Synonyms name
  • TNF superfamily, member 2
• GenBank acession
  • X02910
• Locus
  6p21.33
• Discovery year
  1986-01-01
• Entrez gene record
  7124
• Pubmed identfication
  • 2413547
  • 6392892
• Classification
  • Tumor necrosis factor superfamily
• VEGA ID
  OTTHUMG00000031194

Gene info

• Identity
  HGNC:11916
• Gene
  TNFRSF1A
• Long gene name
  TNF receptor superfamily member 1A
• Synonyms gene
  • TNFR1
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 1A
• Synonyms
  • TNF-R
  • TNFAR
  • TNFR60
  • TNF-R-I
  • CD120a
  • TNF-R55
• GenBank acession
  • M75866
• Locus
  12p13.31
• Discovery year
  1991-01-15
• Entrez gene record
  7132
• Pubmed identfication
  • 1655358
  • 2158863
• RefSeq identity
  • NM_001065
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000168267
• Locus Specific Databases
  • INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
  • LRG_193

Gene info

• Identity
  HGNC:6718
• Gene
  LTBR
• Long gene name
  lymphotoxin beta receptor
• Synonyms gene
  • D12S370
• Synonyms
  • TNFCR
  • TNFR-RP
  • TNFR2-RP
  • TNF-R-III
  • TNFRSF3
• Synonyms name
  • TNFR superfamily, member 3
• GenBank acession
  • L04270
• Locus
  12p13.31
• Discovery year
  1996-03-12
• Entrez gene record
  4055
• Pubmed identfication
  • 8171323
  • 8486360
• Classification
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000168356

Gene info

• Identity
  HGNC:48824
• Gene
  PCAT7
• Long gene name
  prostate cancer associated transcript 7
• Synonyms gene name
  • prostate cancer associated transcript 7 (non-protein coding)
• Synonyms
  • PCAN-R2
• Synonyms name
  • prostate cancer-associated noncoding RNA 2
• Locus
  9q22.32
• Discovery year
  2013-06-14
• Entrez gene record
  101928099
• Pubmed identfication
  • 23728290
• RefSeq identity
  • NR_121566
• Classification
  • Long non-coding RNAs with non-systematic symbols
• VEGA ID
  OTTHUMG00000020270

Gene info

• Identity
  HGNC:6210
• Gene
  CD82
• Long gene name
  CD82 molecule
• Synonyms gene
  • ST6
  • KAI1
• Synonyms gene name
  • kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))
  • CD82 antigen
• Synonyms
  • R2
  • IA4
  • TSPAN27
• Synonyms name
  • suppression of tumorigenicity 6
  • R2 leukocyte antigen
• GenBank acession
  • U20770
• Locus
  11p11.2
• Discovery year
  1994-01-10
• Entrez gene record
  3732
• RefSeq identity
  • NM_002231
• Classification
  • Tetraspanins
  • CD molecules
• VEGA ID
  OTTHUMG00000166472

Gene info

• Identity
  HGNC:2045
• Gene
  CLDN3
• Long gene name
  claudin 3
• Synonyms gene
  • C7orf1
  • CPETR2
• Synonyms
  • RVP1
  • CPE-R2
  • HRVP1
• Synonyms name
  • Clostridium perfringens enterotoxin receptor 2
  • ventral prostate.1-like protein
  • claudin-3
  • CPE-receptor 2
• GenBank acession
  • AF007189
• Locus
  7q11.23
• Discovery year
  1998-07-23
• Entrez gene record
  1365
• Pubmed identfication
  • 9441748
  • 9892664
• RefSeq identity
  • NM_001306
• Classification
  • Claudins
• VEGA ID
  OTTHUMG00000023424

Gene info

• Identity
  HGNC:11905
• Gene
  TNFRSF10B
• Long gene name
  TNF receptor superfamily member 10b
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 10b
• Synonyms
  • DR5
  • KILLER
  • TRICK2A
  • TRAIL-R2
  • TRICKB
  • CD262
  • TRAILR2
• GenBank acession
  • AF012628
• Locus
  8p21.3
• Discovery year
  1998-12-04
• Entrez gene record
  8795
• Pubmed identfication
  • 9285725
  • 9311998
• RefSeq identity
  • NM_147187
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000097826

Gene info

• Identity
  HGNC:11245
• Gene
  SPINK2
• Long gene name
  serine peptidase inhibitor Kazal type 2
• Synonyms gene name
  • serine protease inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
• Synonyms
  • HUSI-II
• Synonyms name
  • acrosin-trypsin inhibitor
• GenBank acession
  • BC022514
• Locus
  4q12
• Discovery year
  1993-12-01
• Entrez gene record
  6691
• Pubmed identfication
  • 8428671
• RefSeq identity
  • NM_021114
• Classification
  • Serine peptidase inhibitors, Kazal type
• VEGA ID
  OTTHUMG00000128769

Gene info

• Identity
  HGNC:2339
• Gene
  CRABP2
• Long gene name
  cellular retinoic acid binding protein 2
• Synonyms gene name
  • cellular retinoic acid-binding protein 2
• Synonyms
  • CRABP-II
• GenBank acession
  • BC001109
• Locus
  1q23.1
• Discovery year
  1992-11-25
• Entrez gene record
  1382
• Pubmed identfication
  • 1654334
• RefSeq identity
  • NM_001878
• Classification
  • Fatty acid binding protein family
• VEGA ID
  OTTHUMG00000041300

MeSH Data

• Name
  Tumor Stem Cell Assay
• Concept
  Scope note: A cytologic technique for measuring the functional capacity of tumor stem cells by assaying their activity. It is used primarily for the in vitro testing of antineoplastic agents.
• Tree numbers
  • E01.370.225.500.383.910
  • E01.370.225.500.388.930
  • E05.200.500.383.910
  • E05.200.500.388.930
  • E05.242.383.910
  • E05.242.417.500
  • E05.337.550.200.800
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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