-
Also known as
CD195
-
Other names
C-C chemokine receptor type 5; C-C chemokine receptor type 5; C-C chemokine receptor type 5; chemr13; HIV-1 fusion coreceptor; chemokine receptor CCR5; C-C motif chemokine receptor 5 A159A; chemokine (C-C motif) receptor 5 (gene/pseudogene); CHEMR13; HIV-1 fusion coreceptor
-
Category
Antibodies
-
Subcategory
Mnoclonal antibodies
-
Gene name
CD195
-
Gene name synonims
N/A
-
Other gene names
CCR5; CCR5; CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5; CMKBR5; C-C CKR-5; CC-CKR-5; CCR-5; CCR5
-
Clonality
Monoclonal
-
Immunoglobulin isotype
IgG2b
-
Clone
V14/2
-
Host organism
Mouse (Mus musculus)
-
Species reactivity
Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
-
Specificity and cross reactivity
CD195 This item is specific for human CD195, a cell surface antigen of approximately 40kD, also known as CCR5. This antibody has been demonstrated to exclusively recognise CD195 phosphorylated at Ser 337 Human CD195 is a member of the G protein coupled superfamily of receptors, which acts as a receptor for a number of chemokines including RANTES and also serves as a co-receptor for the entry of HIV into cells. It plays a key role in regulating the activation and migration of leukocytes. CD195 is expressed by a subset of T lymphocytes and by monocytes. Recent studies have shown that upon ligand stimulation, CD195 is rapidly phosphorylated within the C-terminal domain. This item recognises a band of approximately 40kD on Western blots of RBL-CCR5 cell lysates; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
-
Purification method
N/A
-
Form Appearance
Purified (Purified IgG - liquid)
-
Concentration
IgG concentration 1.0 mg/ml
-
Storage and shipping
Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term.Should the antibody contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of dispatch.
-
Tested applications
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA), Flow Cytometry (FACS)
-
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
-
Properties
If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
Test
MBS Monoclonals supplies antibodies that are for research of human proteins. Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
-
Latin name
Mus musculus
-
French translation
anticorps
