CD71/ Transferrin Receptor

• Catalog number
  GEN438334
• Price
  Please ask
• Size
  100ug

• Also known as
  CD71
• Other names
  transferrin receptor protein 1; Transferrin receptor protein 1; transferrin receptor protein 1; transferrin receptor (p90, CD71); transferrin receptor; T9; p90; CD_antigen: CD71Cleaved into the following chain:Transferrin receptor protein 1, serum form; sTfR
• Category
  Antibodies
• Subcategory
  Mnoclonal antibodies
• Gene name
  TFRC
• Gene name synonims
  N/A
• Other gene names
  TFRC; TFRC; T9; TR; TFR; p90; CD71; TFR1; TRFR; TR; TfR; TfR1; Trfr; sTfR
• Clonality
  Monoclonal
• Immunoglobulin isotype
  IgG1, kappa
• Clone
  66IG10
• Host organism
  Mouse (Mus musculus)
• Species reactivity
  Human (Homo sapiens).; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
• Specificity and cross reactivity
  It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Its epitope is localized in the extracellular domain of CD71. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
• Purification method
  N/A
• Form Appearance
  N/A
• Concentration
  N/A
• Storage and shipping
  Store the antibody at +4C. Temperature variations in the range of 1 to 7 degrees Celsius are tolerable. We recommend NOT to freeze the antibody. Antibody is stable for 24 months.
• Tested applications
  ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistology (IH)
• Description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

• Gene target
  CD71   Transferrin   Receptor  
• Gene symbol
  TFRC
• Short name
  CD71/ Transferrin Receptor
• Alternative name
  Anti-CD71/ Transferrin Receptor

Gene info

• Identity
  HGNC:11763
• Gene
  TFRC
• Long gene name
  transferrin receptor
• Synonyms gene name
  • transferrin receptor (p90, CD71)
• Synonyms
  • CD71
  • TFR1
  • p90
• GenBank acession
  • X01060
• Locus
  3q29
• Discovery year
  2001-06-22
• Entrez gene record
  7037
• Classification
  • M28 metallopeptidases
  • CD molecules
• VEGA ID
  OTTHUMG00000155714

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