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Category
Primary Antibodies
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Long description
Tumor necrosis factor receptor (TNFR) superfamily members are defined by cysteine-rich domains in their extracellular regions that bind TNF-related ligands that share a common structural homology in their extracellular domain. TNFRSF14 was initially identified as the Herpesvirus entry mediator and upon binding to the herpes simplex virus (HSV) envelope glycoprotein D or either of its natural ligands LIGHT and lymphotoxin alpha (LT), activates the transcription factors NF-κB and AP-1. Activation of this signal transduction pathway in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses.
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Antibody come from
Synthetic peptide derived from the human histone deacetylase 1 protein.
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Other description
Provided as ligand affinity purified antibody in phosphate buffered saline with 0.08% sodium azide. Antigen Immunoaffiinity Purification
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Clone
Polyclonal
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Antigen antibody binding interaction
Rabbit anti TNFRSF14 NT (Tumor necrosis factor receptor superfamily 14) Antibody
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Antibody is raised in
Rabbit
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Antibody s reacts with
Human, Mouse
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Antibody s reacts with these species
This antibody doesn't cross react with other species
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Antibody s specificity
No Data Available
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Application
Western Blot
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Antibody s suited for
Antibody can be used for Western blotting (1-5µg/ml). Optimal concentration should be evaluated by serial dilutions.
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Storage
-20ºC
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Relevant references
1. Marmorstein, R. et al. (2001) Cell. Mol. Life Sci. 58, 693-703._x000B__x000B_2. Gray, S.G. and Ekstrom, T.J. (2001) Exp. Cell Res. 262, 75-83._x000B__x000B_3. Thiagalingam, S. et al. (2003) Ann. N. Y. Acad. Sci. 983, 84-100._x000B__x000B_4. Viguishin, D.M. and Coombes, R.C. (2004) Curr. Cancer Drug Targets 4, 205-218._x000B__x000B_5.J Virol. 2006 Dec 6; Mapping of key functions of the herpes simplex virus 1 US3 protein kinase: the US3 protein can form functional heteromultimeric structures derived from overlapping truncated polypeptides. Alice P W Poon, Bernard Roizman_x000B__x000B_6. J Biol Chem. 2006 Nov 22; Molecular mechanisms of trans-activation and doxorubicin mediated repression of survivin gene in cancer cells. _x000B_Pierre-Olivier Esteve, Hang Gyeong Chin, Sriharsa Pradhan_x000B__x000B_7. Curr Drug Targets. 2006 Nov ;7(11):1553-60: The role of NAD+ dependent histone deacetylases (sirtuins) in ageing. Johannes Trapp, Manfred Jung_x000B__x000B_8. Circ Res. 2006 Nov 2; Transcriptional Silencing of the Death Gene BNIP3 by Cooperative Action of NF-B and Histone Deacetylase 1 in Ventricular Myocytes. James Shaw, Tong Zhang, Marek Rzeszutek, Natalia Yurkova, Delphine Baetz, James R Davie, Lorrie A Kirshenbau
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Protein number
see ncbi
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Warnings
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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About
Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin name
Oryctolagus cuniculus